Recent advances in low‐background luminescent nanomaterials‐enhanced lateral flow assays for clinical diagnosis

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Lateral flow assays (LFAs) are widely applicable in clinical point‐of‐care testing (POCT) due to their unique advantages such as simplicity, rapidity, and cost‐effectiveness. However, sensitivity is often constrained by the background autofluorescence of biological sample, self‐matrix, or readout technique, thereby leading overlooking trace amounts biomarkers present early disease. In recent years, various nanomaterials‐based methods have been developed address this issue, including time‐gated wavelength‐differentiated strategy external modulated for separation minimize interference from samples. This review provides a comprehensive overview low‐background luminescent nanoparticles (LBLNPs)‐enhanced LFA systems, focusing on analyzing underlying mechanism these nanomaterials improving accuracy LFAs platform diagnosis. Representative examples selected demonstrate potential detecting disease‐associated samples blood, urine, saliva et al. Finally, unresolved challenges future development prospects briefly discussed.

Language: Английский

---

Heavy Atom Effect on T_n (n ≥ 2) Afterglow

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract The properties of higher triplet excited states (T n , ≥ 2) are essential for deep understanding state dynamics, but direct observation T phosphorescence remains rare, let alone systematic studies behaviors based on well‐designed luminescence molecules. Recently, a serendipitous finding (n afterglow (phosphorescence lifetime > 0.1 s) in benzophenone‐containing difluoroboron β‐diketonate (BPBF 2 ) system is communicated. Here Cl/Br/I atoms covalently incorporated into BPBF molecules and report the first study heavy atom effect (HAE) afterglow. It known that HAE has been widely reported thoroughly studied 1 systems, which shows Br usually optimized selection balancing efficiency lifetime. In contrast, covalent linkage to found dramatically suppress experimental emission intensity(T )/intensity(T ratios positively correlated with k IC −T )/ × P ), where refer rates calculated internal conversion emission. These fundamental would be helpful elucidating panorama Perrin‐Jablonski diagram organic systems provide intriguing materials future applications.

Language: Английский

---

Achieving High‐Performance Organic Long Persistent Luminescence Materials via Manipulation of Radical Cation Stability

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Abstract Organic long persistent luminescence (OLPL) materials, with their hour‐long afterglow, hold great promise across numerous applications, yet performance lags behind that of inorganic counterparts. A deeper understanding the underlying photophysical mechanisms, particularly effective control radical intermediates, is essential for developing high‐performance OLPL materials; while systematic studies on intrinsic stability intermediates and impact remain scarce. Here biphenyl groups introduced into a luminophore‐matrix‐donor three‐component system. By varying substituents at ortho‐position groups, cations systematically modulated, influence properties investigated. Combined experimental results theoretical calculations reveal increased flexibility bond adjustable conformations lead to higher cations, thereby significantly enhancing performance. Based this understanding, luminophore two designed successfully achieve remarkable afterglow brightness close Sr 2 Al 14 O 25 /Eu 2+ , Dy 3+ materials. Furthermore, these materials exhibit time‐encoded promising applications in advanced anti‐counterfeiting, as well background‐independent bioimaging functions. This work not only provides novel strategy constructing but also lays foundation widespread application various fields.

Language: Английский

---

Fine regulation of charge recombination for multi-color persistent luminescence

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

---

Pure Organic Thermally Activated Delayed Fluorescence Afterglow Polymers via Dopant Isomerization

ACS Macro Letters, Journal Year: 2025, Volume and Issue: unknown, P. 265 - 271

Published: Feb. 13, 2025

N-(o-Cyanophenyl)carbazole can be dimerized at different positions, which may change excited state behaviors. Herein, 2,3′-dicyano-3,4′-di(carbazol-9-yl)biphenyl (D34C) is designed and synthesized doped into polymers. However, we find that D34C does not exhibit room temperature phosphorescence but emits fluorescence (FL) bright thermally activated delayed (TADF) with lifetimes of hundreds milliseconds, observed in diverse matrices such as PMMA, MBS, ABS, PS, HIPS, SIS. The simple positional isomerization makes the abundant triplet excitons undergo only reverse intersystem crossing rather than (RTP) radiation, rare organic Since production TADF afterglow requires a certain excitation time, generally indistinguishable FL efficiencies are separated for first time. This work provides novel polymers mechanical properties also will evoke subtle design conjugated molecules to dramatically photoexcitation emission

Language: Английский

---

Reconfigured Spin-Flip Process Enables Efficient and Persistent Triplet Excitons in Organic–Inorganic Metal Halides

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Triplet excitons, driven by spin-flip processes, play a crucial role in enabling efficient room-temperature phosphorescence across various applications. However, attaining significant accumulation of long-lived excitons is impeded the simultaneous influence nonradiative and radiative decay pathways alongside intersystem crossing efficiencies. Here, we introduce solvent intercalation approach that leverages triplet exciton processes family zero-dimensional organic-inorganic halides, A2ZnBr4 (A = organic phosphonium cations). By intercalating inactive molecules into these their can be reconfigured. This leads to significantly amplified but attenuated transitions, which give rise 16- 6-fold increases lifetime quantum yield, respectively. Our single crystal X-ray diffraction, transient absorption, theoretical calculation results reveal such dramatic improvement attributed unique spatial effect on both electrons holes induced intercalated molecules. The consequently reduced orbital degeneracy number spin-allowed channels, promoting crossing, while synergistically enhanced electron localization diminishes decay, leading high efficiency enduring phosphorescence. findings offer new pathway for manipulating process boost emission with potential applications designing wide spectrum phosphorescent materials.

Language: Английский

---

Thermally Activated Delayed Fluorescence-Type Organic Afterglow Emitters for Devising Organic Long Persistent Luminescence Materials

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1313 - 1320

Published: March 10, 2025

Language: Английский

---

Ultralong Room Temperature Phosphorescence through Both Space Confinement and Long-Range Charge Migration

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Doping guest materials into host with a confined space to suppress nonradiative decay is an effective strategy for achieving room-temperature phosphorescence (RTP). However, constructing host–guest doped ultralong RTP (URTP) still challenging. Herein, by embedding three coumarin derivatives boric acid via one-step heat treatment, the URTP material afterglow lasting up 60 s, lifetime of 1.59 and quantum yield 18.14% was successfully prepared. Experimental results show that dense 3D boron oxide network formed after along B–O covalent bonds O→B coordination between guest, effectively suppresses transitions through both physical chemical confinement. More importantly, oxygen vacancy defects in during combined charge-separated states generated molecules upon irradiation, together facilitated long-range charge migration process. In addition, recombination accompanied long-lived emission. Finally, prepared exhibit potential applications encryption decryption information security fields.

Language: Английский

---

Dual-Ring-Locking Strategy Enables Persistent Blue Room Temperature Phosphorescence in Benzo[b]phospholiums

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Commercial phosphines and phosphoniums were commonly reported to have unstable triplet dissipation because of the flexible C-P pyramidal geometry, resulting in extremely weak or no phosphorescence. To boost populations stability by restricting molecular motion rebuilding electronic structures, we that dual-ring-locking strategy could enable elevated intersystem crossing (ISC) radiation for rigid benzo[b]phospholium configuration, exhibiting intense persistent room temperature phosphorescence (RTP) poly(vinyl alcohol) (PVA). Among them, dual-ring-locked [P1]+[Cl]- showed near-ultraviolet fluorescence maximized at 400 nm dichloromethane blue RTP emission 453 (Φphos ≈ 12.4%, τphos > 1200 ms) PVA matrix. In contrast, [P2]+[Cl]- possessed a single ring-locked nucleus had red-shifted < 1.8%, = 74.2 ms). Time-dependent density functional theory (TD-DFT) disclosed improved spin-flipping benefited from integrated π-π*/n-π* transition, rational split energy, excited states. The impressive OU-RTP duration function as an afterglow pattern optical encryption emitting layer light-emitting diode (LED) applications.

Language: Английский

---

Organic Ionic Host–Guest Phosphor with Dual-Confined Nonradiation for Constructing Ultrahigh-Temperature X-ray Scintillator

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Scintillators with X-ray-excitable luminescence have attracted great attention in the fields of medical radiography, nondestructive inspection, and high-energy physics. However, thermal quenching significantly reduces radioluminescence efficiency, particularly for those phosphorescent scintillators promising radiation-induced triplet exciton utilization, ultimately limiting their applications high-temperature scenarios. Herein, we develop ultrahigh-temperature based on organic ionic host–guest phosphorescence systems unprecedented thermal-stable emissions up to 673 K. The guest phosphor features spin-vibronic coupling-assisted intersystem crossing, effectively transforming thermally activated delayed fluorescence overcoming inactivation excitons. Meanwhile, rigid host robust electrostatic interactions minimize both intrinsic extrinsic nonradiations excitons, so-called dual-confined nonradiation. These two mechanisms work synergistically, contributing highly efficient exciton-based a room-temperature efficiency 38.7% ultrahigh-temperature-resistant dual emissions. Such an innovative scintillator achieves impressively low X-ray detection limit 71.5 nGy s–1 remarkably bright photoluminescence (efficiency 80.4% at 483 K), enabling imaging.

Language: Английский

---