Bimolecular Homolytic Substitution (SH2) at A Transition Metal

ChemCatChem, Journal Year: 2024, Volume and Issue: 16(21)

Published: Aug. 8, 2024

Abstract Transition metal‐catalyzed cross‐coupling reactions have become a powerful and widely used synthetic approach for the construction of both carbon‐carbon carbon‐heteroatom bonds. These revolutionized chemistry by enabling efficient formation complex molecular architectures. Among various methods available, bimolecular homolytic substitution (S H 2) reaction has emerged as an attractive versatile method C(sp 3 )−C(sp ) )‐heteroatom In recent years, significant progress been made in development radical S 2 reactions, particularly those involving different transition metal complexes such cobalt, nickel, iron. advancements expanded scope allowing greater diversity substrate compatibility conditions. this review, we aim to highlight latest breakthroughs mechanistic insights into focusing on role catalysts facilitating these transformations. We will discuss types that employed, pathways involved, potential applications synthesis organic molecules.

Language: Английский

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Recent Advances in Photoinduced Borylation via N-Heterocyclic Carbene Boryl Radicals

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Abstract Organoboron compounds are recognized as essential synthetic intermediates in organic chemistry and have found broad applications pharmaceutical materials science. In recent years, the development of novel boronating reagents has opened new avenues for synthesis organoboron compounds. Among these, N-heterocyclic carbene boranes (NHC-boranes), with their unique advantages, garnered sustained interest evolved into important precursors boron-centered radicals, participating a diverse array visible-light-induced borylation reactions. This short review primarily focuses on radical reactions involving NHC-boranes, summarizing latest advancements field offering inspiration subsequent research. 1 Introduction 2 Photoinduced Borylation via NHC-Boryl Radicals 2.1 Polyfluoroarenes 2.2 Arenes 2.3 Alkenes 2.4 Alkynes 2.5 Other Substrates 3 Conclusion Future Prospects

Language: Английский

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Manganese-Catalyzed Cycloalkene Ring Expansion Synthesis of Azaheterocycles

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Herein, a Mn catalytic protocol has been developed for the cycloalkene ring expansion synthesis of azaheterocycles, allowing broad-substrate-scope access to pyridine and isoquinoline derivatives. The initial monoaddition an azidyl radical alkene further as-generated C-radical addition O

Language: Английский

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