Deciphering the Antibacterial Mechanism of Hollow Sphere Metal–Organic Frameworks against Staphylococcus aureus and Its Application in Wound Healing

Chemistry of Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Staphylococcus aureus infection and antimicrobial resistance (AMR) to antibiotics are two significant factors that pose escalating threats public health, potentially leading persistent pain or even death. Consequently, there is an urgent need for the development of alternative antibacterial materials. In this study, we have successfully developed a biocompatible nanosystem based on hollow spherical zeolitic imidazolate framework-67 (ZIF-67 HS), which exhibits remarkable bactericidal efficacy against Gram-positive S. both in vitro vivo. Importantly, our findings demonstrate prolonged exposure subminimum inhibitory concentrations ZIF-67 HS does not induce secondary as observed with conventional antibiotics; instead, it maintains sustained susceptibility toward antibiotic-resistant strains. Multiomics analyses (including transcriptomics, metabolomics, metalomics) indicated regulates 95 genes, 261 metabolites, 2 metal elements aureus. Through bioinformatics analysis combination bioassays, demonstrated disrupted multiple essential pathways pathogen, including amino acid metabolism, iron membrane transport, reactive oxygen species (ROS), pathways. Our suggest induces bacterial death through mechanisms rather than single target highlight its long-lasting properties. This study presents valuable insights into potential nanobiomedicine eradicating bacteria elucidates related molecular mechanism.

Language: Английский

Injectable carboxymethyl chitosan/konjac glucomannan/catechin hydrogel with free radical-scavenging, antimicrobial, and pro-healing abilities for infected wound repair

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142572 - 142572

Published: March 1, 2025

Language: Английский

Recent advances in tea and other plant polyphenol biomaterials for antibacterial and disease treatment

Beverage Plant Research, Journal Year: 2025, Volume and Issue: 5(1), P. 0 - 0

Published: Jan. 1, 2025

Language: Английский