Nucleic Acid‐Locked Smart Carrier for Photothermal/Chemotherapy‐Amplified Immunogenic Cell Death to Enhance Systemic Antitumor Efficacy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Immunotherapy holds great promise in the fight against cancer; however, it often encounters poor immunogenicity with limited therapeutic efficacy. Combining multiple treatment modalities provides a trustworthy strategy for achieving robust antitumor effect. In this study, nucleic acid‐locked smart carrier (NASC) is developed to amplify immunogenic cell death (ICD) through synergistic integration of photothermal therapy (PTT) and chemotherapy high‐performance monotherapy. Mesoporous silica‐coated gold nanorod (MSGNR) serves as reservoir anticancer drug doxorubicin (DOX) capped sequence‐specific duplex unit containing tumor‐specific targeting AS1411 fragment, resulting formation NASC. With targeting, NASC can specifically target be internalized into tumor cells high expression nucleolin, where capping unlocked by intracellularly overexpressed adenosine triphosphate. Subsequently, released DOX synergized MSGNR‐mediated PTT following laser irradiation induces direct killing, which, concurrently, triggers ICD activate antineoplastic immunity an increased number T lymphocytes. This triple‐collaborative strategy, further combined anti‐programmed death‐1 antibody (αPD‐1)‐mediated immune checkpoint blockade (ICB) therapy, shows efficacy both unilateral bilateral models.

Language: Английский

Advances in CRISPR/Cas13a-based biosensors for non-coding RNA detection

Talanta, Journal Year: 2025, Volume and Issue: 294, P. 128223 - 128223

Published: April 25, 2025

Language: Английский