Immunity‐Modulating Metal‐Based Nanomaterials for Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Cancer immunotherapy, which leverages the body's immune system to combat cancer, offers promise of lower toxicity and higher therapeutic efficacy compared conventional treatments. However, current immunotherapeutic approaches face significant challenges including variable patient response, immune‐related adverse events, high costs, underscoring urgent need for innovative strategies. Metal‐based nanomaterials have emerged as a promising avenue in cancer immunotherapy due their unique physicochemical properties immune‐regulating capabilities. Despite potential, concerns about toxicity, incomplete understanding modulation mechanisms, early‐stage design strategies hinder clinical translation. This review summarizes recent advancements metal‐based elucidates mechanisms by they enhance antitumor immunity responses, explores potential synergistic effects combining multiple metals. We also discuss key future perspectives application, aiming provide theoretical foundation development immunotherapies promote broader application treatment.

Language: Английский

Gallium‐Magnesium Layered Double Hydroxide for Elevated Tumor Immunotherapy Through Multi‐Network Synergistic Regulation

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Immunotherapeutic efficacy is often limited by poor immunogenicity, immunosuppressive tumor microenvironment (TME), and cytoprotective mechanisms, leading to low immune activation. To this end, here, L‐amino acid oxidase (LAAO) loaded gallium‐magnesium layered double hydroxide (MG‐LAAO) prepared for significantly enhanced immunotherapy through multi‐network synergistic regulation. First, MG‐LAAO induces cell pyroptosis initiating caspase‐1/GSDMD caspase‐3/GSDME pathways, further triggering immunogenic death (ICD). Then the released Ga 3+ mitochondrial iron overload, resulting in ferroptosis. In addition, also hinders autophagy of cells, reshapes (TME) neutralizing H + inhibiting lactic accumulation, thus destroying mechanism avoiding escape. Furthermore, synergy activates cGAS‐STING signaling pathway, generating powerful antitumor immunotherapy. This work highlights critical role synergies between block, pyroptosis, ferroptosis, ICD immunotherapy, demonstrating important effectively overcoming TME enhancing immunogenicity. particular, gallium‐induced revealed first time, providing theoretical support design new materials future.

Language: Английский

Shining a light on pyroptosis in cancer chemotherapy by multi-modal imaging with a dual-channel nanoreporter

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163018 - 163018

Published: April 1, 2025

Language: Английский