De Novo Design of Efficient NIR‐II‐Activated Heavy‐Atom‐Free Type‐I Photosensitizer for Anti‐Tumor Photoimmunotherapy DOI
Huan Chen, Yu Wang,

Zhangxin He

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: June 4, 2025

Abstract Type‐I photosensitizers (PSs) are considered to be efficient agents for overcoming the oxygen‐dependent deficiency of traditional photodynamic therapy (PDT). However, it is still challenging design type‐I PSs that can activated by second near‐infrared (NIR‐II) irradiation. Herein, a series organic heavy‐atom‐free molecules designed (named as CTU1 , CTU2 and CTU3 ) exhibit strong absorption bands over first NIR‐II regions. Among them, water‐dispersible nanoparticles (NPs) show J ‐aggregate characteristics good band, resulting in highly •O 2 − generation upon irradiation 1064 nm light. In addition, NPs also high photothermal conversion efficiency 88.6%. vitro vivo experiments have superior PDT (PTT) effects, which further induce immunogenic cell death activate immune cells 4T1 tumor‐bearing mice combined PDT/PTT anti‐tumor photoimmunotherapy against refractory tumors. This work presents paradigm de novo light‐activated PS combinational cancer.

Language: Английский

Cancer Specific CAIX‐Targeting Supramolecular Lysosome‐Targeting Chimeras (Supra‐LYTAC) for Targeted Protein Degradation DOI Creative Commons
Do‐Hyun Kim,

Gyeongseok Yang,

Chaelyeong Lim

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable proteins. While most TPD target intracellular proteins, limited options exist for targeting extracellular or membrane Herein, cancer specific carbonic anhydrase IX (CAIX)-targeting supramolecular nanofibrous lysosome-targeting chimeras (Supra-LYTAC) is reported. Two self-assembling amphiphilic peptides are synthesized: one that interacts with the of interest (POI), and another mediates lysosomal endocytosis by cancer-specific enzyme. Notably, these two co-assemble into nanofibers capable cells in spatiotemporal manner. Through dynamic multivalent binding, ternary complex form (supramolecular chimeric nanostructure; CAIX-nanofiber-POI), which undergoes internalization lysosomes where POI degraded through catalytic activity. This study demonstrates potential approaches expand scope LYTAC technology, offering new opportunities designing future.

Language: Английский

Citations

1
Combating cancer immunotherapy resistance: a nano‐medicine perspective DOI Creative Commons
Xiangyi Kong, Xintong Xie, Juan Wu

et al.

Cancer Communications, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading resistance. Various functionalized nanoparticles (NPs), modified with cationic lipids, pH‐sensitive compounds, or photosensitizers, exhibit unique physicochemical properties facilitate targeted delivery therapeutic agents tumor microenvironment (TME). These NPs are engineered modify activity. The crucial signal transduction pathways by which counteract resistance outlined, including enhancing antigen presentation, boosting activation infiltration tumor‐specific cells, inducing immunogenic cell death, counteracting immunosuppressive conditions in TME. Additionally, review summarizes current clinical trials involving NP‐based immunotherapy. Ultimately, it highlights potential nanotechnology advance

Language: Английский

Citations

0
Development and Application of Organic Sonosensitizers in Cancer Therapy DOI Creative Commons
Yuhan Ding,

Yuchen Yang,

Ömer Aras

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.

Language: Английский

Citations

0
A Chiral Amino Acid-Modified pH-Responsive Nanoplatform Coactivates Cuproptosis and cGAS-STING Signaling Pathways for Cancer Therapy DOI
Lin Li,

G H Wang,

Benchu Xue

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1973 - 1983

Published: April 21, 2025

Language: Английский

Citations

0
Recent Advances and Future Prospects in Biological-Membrane-Targeted Polymers DOI Creative Commons
Ran Chen, Yaping Liu, Yanan Jiang

et al.

Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

Citations

0
Ultrasound-responsive nanoweapons: covalent organic frameworks for cancer sonodynamic therapy DOI
Yu Shrike Zhang, Chunyuan Hou, Bin Zhu

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Sonodynamic therapy (SDT), characterized by its non-invasiveness, low toxicity, and deep tissue penetration, has emerged as a promising therapeutic modality for anticancer treatments. Recently, covalent organic frameworks (COFs) have garnered significant attention in the SDT realm powerful versatile toolbox. Notably, COF-based achieved many encouraging outcomes owing to remarkable potential of COFs, volume related research experienced continuous growth. Therefore, we strive provide timely comprehensive review that thoroughly summarizes advancements SDT. This begins with concise yet summary ultrasonic cavitation sonodynamic effects, elucidating fundamental principles mechanisms Subsequently, it delves into chemistry examining intricate structure designs, various types linkages, diverse synthetic methods. The primary focus this is summarize sonosensitizers, including construction strategies product properties. More importantly, role COFs combined therapies described detail, aiming highlight advantages COF-enhanced synergistic Finally, points out current challenges future opportunities rapidly evolving field. Overall, deliberations overviews sonosensitizers are expected facilitate advancements, leading early-stage clinical benefits patients.

Language: Английский

Citations

0
Biomimetic Hybrid PROTAC Nanovesicles Block Multiple DNA Repair Pathways to Overcome Temozolomide Resistance Against Orthotopic Glioblastoma DOI
Qing Xu, Xing Hu, Ihsan Ullah

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Glioblastoma (GBM) remains one of the deadliest forms cancer due to its high rates postoperative recurrence and resistance treatment. Temozolomide (TMZ) is standard chemotherapy for GBM. However, therapeutic efficacy TMZ significantly compromised by activation various intracellular DNA repair mechanisms that facilitate resistance. Herein, upregulation bromodomain‐containing protein 4 (BRD4) expression demonstrated be a key contributor in To address this challenge, biomimetic hybrid PROteolysis TArgeting Chimeras (PROTAC) liposome delivery system (M@TP) developed. This efficiently penetrates blood‐brain barrier (BBB) specifically targets GBM cells through homotypic recognition. Once within TMZ‐resistant cells, released PROTAC from M@TP can degrade BRD4, effectively inhibiting multiple pathways restoring sensitivity In vivo, studies showed significant suppressing tumor growth both GBM, with prolonged mouse survival times. These findings highlight potential as promising strategy overcome improve outcomes

Language: Английский

Citations

0
Lymphocyte‐Mimicking Sonosensitizers Boost Cancer Immunotherapy via Sequential Ultrasound Activation DOI
Jiawei Zhu, Xiaorui Wang, Runtao Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 24, 2025

Abstract Effective initiation of the cancer‐immunity cycle is core challenge tumor immunotherapy, which relies on coordinated antigen release and immunostimulation. To address this issue, work introduced a novel lymphocyte‐mimicking sonosensitizer using Mn‐doped hollow Prussian blue nanoparticle (Mn‐HP) for cancer sonodynamic therapy (SDT) to efficiently evoke anticancer immunity. The prepared Mn‐HP have unique architecture amplify ultrasonic cavitation effects, boosting spatially controlled reactive oxygen species (ROS) production. Through effective combination lymphocytes, Lymphocyte‐mimicking (Lymphocytes‐Mn‐HP, LM) with “Homing effect” constructed. sequenced dual‐ultrasound strategy employs high‐power ultrasound (2.0 W cm −2 ) stimulation (excessive ROS) low‐power (0.5 (moderate lymph node active immune cells, enabling precise spatial‐temporal ROS generation while preserving function. Both in vitro vivo studies demonstrated significant suppression through initiating cycle, offering transformative paradigm SDT‐immunotherapy integration.

Language: Английский

Citations

0
De Novo Design of Efficient NIR‐II‐Activated Heavy‐Atom‐Free Type‐I Photosensitizer for Anti‐Tumor Photoimmunotherapy DOI
Huan Chen, Yu Wang,

Zhangxin He

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: June 4, 2025

Abstract Type‐I photosensitizers (PSs) are considered to be efficient agents for overcoming the oxygen‐dependent deficiency of traditional photodynamic therapy (PDT). However, it is still challenging design type‐I PSs that can activated by second near‐infrared (NIR‐II) irradiation. Herein, a series organic heavy‐atom‐free molecules designed (named as CTU1 , CTU2 and CTU3 ) exhibit strong absorption bands over first NIR‐II regions. Among them, water‐dispersible nanoparticles (NPs) show J ‐aggregate characteristics good band, resulting in highly •O 2 − generation upon irradiation 1064 nm light. In addition, NPs also high photothermal conversion efficiency 88.6%. vitro vivo experiments have superior PDT (PTT) effects, which further induce immunogenic cell death activate immune cells 4T1 tumor‐bearing mice combined PDT/PTT anti‐tumor photoimmunotherapy against refractory tumors. This work presents paradigm de novo light‐activated PS combinational cancer.

Language: Английский

Citations

0