Biomimetic NIR-II Aggregation-Induced Emission Nanoparticles for Targeted Photothermal Therapy of Ovarian Cancer

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Photothermal therapy (PTT) is a cutting-edge technique that harnesses light energy and converts it into heat for precise tumor ablation. By employing photothermal agents to selectively generate target cancer cells, PTT has emerged as promising treatment strategy. Notably, therapies conducted in the second near-infrared (NIR-II) window exhibit superior therapeutic outcomes, owing deeper tissue penetration reduced scattering. In this study, we developed biomimetic NIR-II aggregation-induced emission (AIE) nanoparticles (2TB-NPs@TM) high-efficiency imaging targeted phototherapy of ovarian cancer. The core nanoparticle aggregates (2TB-NPs) display strong fluorescence high conversion efficiency, while outer cell membrane coating facilitates active targeting recognition tissues. This design imparts excellent biocompatibility enhances drug delivery leading potent synergistic effects. Our findings open new avenues advancing targeted, high-performance diagnostics treatment.

Language: Английский

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Photocatalyzed elaboration of antibody-based bioconjugates

Beilstein Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 21, P. 616 - 629

Published: March 18, 2025

Antibody–drug conjugates (ADCs) represent a promising class of targeted therapeutics, combining the specificity antibodies with potency cytotoxic drugs to enhance therapeutic efficacy while minimizing off-target effects. The development new chemical methods for bioconjugation is essential generate ADCs and optimize their stability, efficacy, safety. Traditional conjugation often face challenges related site-selectivity heterogeneous product mixtures, highlighting need develop new, innovative strategies. Photoredox chemistry emerges as powerful tool in this context, enabling precise, mild, selective modifications peptides proteins. By harnessing light drive transformations, photoredox techniques can facilitate synthesis antibody bioconjugates. This perspective will discuss empower applied functionalization.

Language: Английский

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Switchable Nanophotosensitizers as Pyroptosis Inducers for Targeted Boosting of Antitumor Photoimmunotherapy

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Photodynamic therapy (PDT) has emerged as a promising modality for cancer treatment, but its clinical application is constrained by unexpected phototoxicity arising from nonspecific photosensitizer activation and their "always-on" nature. Herein, we developed switchable nanophotosensitizer, poly(cation-π) nanoparticles (NP), which achieves supramolecular assembly through cation-π interactions. By coupling choline cationic moieties with aromatic photosensitizers (ZnPc), the polymer facilitates self-assembly driven interactions NP engineering. Surprisingly, photoactivity of ZnPc was completely quenched upon complexation via interactions, thereby significantly avoiding skin phototoxicity. Upon targeting tumor cells, undergoes GSH-responsive degradation process that weakens leading to spontaneous restoration amplifying immunogenic pyroptosis. In vivo studies demonstrated achieved high inhibition rate 84% while effectively This work provides novel perspective enhancing safety efficacy PDT-based treatment.

Language: Английский

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BODIPY-Based Small Molecular Probes for Fluorescence and Photoacoustic Dual-modality Imaging of Superoxide Anion in Vivo

Talanta, Journal Year: 2025, Volume and Issue: 294, P. 128269 - 128269

Published: May 3, 2025

Language: Английский

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