Enantioselective Cobalt(III)-Catalyzed [4 + 1] Annulation of Benzamides: Cyclopropenes as One-Carbon Synthons DOI Creative Commons
Lenin Kumar Verdhi, Matthew D. Wodrich, Nicolai Cramer

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

A chiral cyclopentadienyl cobalt(III)-catalyzed enantioselective [4 + 1] annulation of N-chlorobenzamides with cyclopropenes is reported. The cobalt catalyst engages in the C-H activation as well promotes C-C bond cleavage cyclopropene, rendering it a one-carbon unit for annulation. reaction efficiently constructs biologically relevant isoindolinones selectivities up to 99:1 er and >20:1 E/Z ratios. cobalt(III) displays unique orthogonal reactivity profile delivering products, whereas its rhodium(III) homologue more classical 2] pattern. Computational studies reveal origin these divergences.

Language: Английский

Enantioselective Cobalt(III)-Catalyzed [4 + 1] Annulation of Benzamides: Cyclopropenes as One-Carbon Synthons DOI Creative Commons
Lenin Kumar Verdhi, Matthew D. Wodrich, Nicolai Cramer

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

A chiral cyclopentadienyl cobalt(III)-catalyzed enantioselective [4 + 1] annulation of N-chlorobenzamides with cyclopropenes is reported. The cobalt catalyst engages in the C-H activation as well promotes C-C bond cleavage cyclopropene, rendering it a one-carbon unit for annulation. reaction efficiently constructs biologically relevant isoindolinones selectivities up to 99:1 er and >20:1 E/Z ratios. cobalt(III) displays unique orthogonal reactivity profile delivering products, whereas its rhodium(III) homologue more classical 2] pattern. Computational studies reveal origin these divergences.

Language: Английский

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