Dual Ratiometric Single-Molecule Theranostic Probes for Photothermal Therapy and Real-Time Quantitative Evaluation of Therapeutic Efficacy In Vivo DOI
Shuping Zhang, Xingyue Liu, Bang‐Ping Jiang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 30, 2025

Tracking the quantitative evaluation of therapeutic efficiency in tumors is essential for precision management cancer patients. Theranostic probes, which integrate diagnostic molecular imaging and capabilities into a single entity, can be used to monitor treatment process reflect effect. However, current theranostic probes lack precise evaluations vivo due use single-wavelength during tumor therapy. Here we present portal library dual ratiometric single-molecule therapy through photothermal (PTT) cell death via near-infrared fluorescence (NIRF) photoacoustic (PA) imaging. One optimal dye further modified an activatable probe (AF-1F-NO2), whose NIRF/PA signal activity are only activated presence biomarker (nitroreductase). By eliciting response (NIRF/PA: NIRF850/NIRF750; PA770/PA670) hypoxia, new acts as hypoxia-activated PTT agent, enabling real-time PTT. Thus, this study not presents first efficacy vivo, but also opens up promising paradigm engineering other combination with more modalities medicine.

Language: Английский

Rationally Manipulating Molecular Planarity to Improve Molar Absorptivity, NIR-II Brightness, and Photothermal Effect for Tumor Phototheranostics DOI

Chaoqi Song,

Shiping Yang,

Yajing Chi

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123113 - 123113

Published: Jan. 17, 2025

Language: Английский

Citations

2
Second Near‐Infrared Window Fluorescence Materials for In Vivo Dynamic Multiplexed Imaging DOI
Fang Fan, Kai Zeng, Yingying Zhu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract Second near‐infrared (NIR‐II) fluorescence imaging has emerged as a breakthrough technology for accurately revealing complex mechanisms in vivo owing to its high sensitivity, deeper tissue penetration, spatiotemporal resolution, and throughput. This review provides comprehensive overview of NIR‐II imaging, specifically focusing on the materials used, including single‐walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare‐earth nanoparticles (RENPs), organic fluorophores (OFs). It details their development, application, advantageous performance imaging. Furthermore, this highlights an approach dynamic multiplexed that enables multitarget detection, providing powerful tool effectively assessing pathological processes biological vivo. Finally, it explores aspects translational medicine addressing challenges, future prospects related material detection equipment, unmet biomedical applications.

Language: Английский

Citations

1
Dynamic Pathophysiological Insight into the Brain by NIR‐II Imaging DOI Creative Commons
Si Chen, Hao Chen, Xinxin Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Cerebral collateral circulation and blood-brain barrier (BBB) are critically required to maintain the normal brain functions, a fact stressing need for accurate in vivo diagnostic tools that can afford valuable pathophysiological insight into functioning of neurovascular unit space time. Currently, understanding perfusion BBB evolution under both physiological pathological conditions remains sparse, largely owing limitations methods recording diminutive route cerebral blood flow. Here, it is reported highly crystalline semiconducting organic nanoprobes (named 4T-BSA) composed small-molecule dye bovine serum albumin showed vast potential live-brain vascular imaging second near-infrared window (NIR-II, 1000-1700 nm). The 4T-BSA had superior penetration depth intact mouse with high signal-to-background ratio (SBR) 6.0 down sub-50-µm spatial resolution vasculature three typical models neurological pathophysiology. By visualizing leakage, identified activities associated arterial/venous flow network disruption. It anticipated NIR-II disruption will bring broad opportunities address major medical challenges across timely, protective, restorative interventions diseases.

Language: Английский

Citations

0
Regulation of AIE activity of bis(4-ethylphenylethynyl)platinum(II) complex based on 4,4′-divinyl-2,2′-bipyridine ligand and its application in the development of “turn-on” type ag+ luminescent probe DOI
Mengmeng Cai, Bolun Zhang, Jianjun Zhang

et al.

Inorganica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 122719 - 122719

Published: April 1, 2025

Language: Английский

Citations

0
Cyclized polyacrylonitrile Nanoparticles: Enhanced intratumoral delivery by photocatalysis and collagen denaturation DOI

Zichuang Xu,

Shurui Zhang,

Xuwu Zhang

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 696, P. 137829 - 137829

Published: May 8, 2025

Language: Английский

Citations

0
Motion and Stillness Integration Over BP Nanocrystalline Complexion for Fasting Charging and Ultrastable Potassium Storage DOI
Guohui Qin, Jiannong Wang, Qingxiang Wang

et al.

Advanced Energy Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 28, 2025

Abstract Black phosphorus (BP) has attracted propagated attention in favorable K + storage featured with its large interlamellar spacing and the commendable fast‐charging performance. Nevertheless, deficient interface stability andante sluggish kinetics, especially referring to high C‐rates, seriously constrain augmented practical application. Herein, Lewis acid‐base‐driven in‐situ transformation via motion stillness integration strategy (LMMS) targeted for a BP complex crown‐ring (CR) structure, transforming into linear side‐chain (LS) structured polymer, is proposed. nanocrystalline enclosed by hollow S, N co‐doped carbon nanoreactor incubated Co/Ni single atoms, nested poly(N‐isopropylacrylamide) grafted polypyrrole macrocyclic polymer (PPM), i.e., CoNi‐SNC@BP@PPM. Based on breaking of C─S bond, more symmetric PPM transformed asymmetric motional PPO crosslinked composite. Such composite merges advantages both excellent (Chain polymers polypyrrole‐grafted networks) expedited achieves discharge capacity 303.9 mAh g −1 after 500 cycles retention rate 81.8%. The works highlights metastable supramolecular toward equilibrated ultrafast‐charging ultrastable even at extreme conditions.

Language: Английский

Citations

0
Dual Ratiometric Single-Molecule Theranostic Probes for Photothermal Therapy and Real-Time Quantitative Evaluation of Therapeutic Efficacy In Vivo DOI
Shuping Zhang, Xingyue Liu, Bang‐Ping Jiang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 30, 2025

Tracking the quantitative evaluation of therapeutic efficiency in tumors is essential for precision management cancer patients. Theranostic probes, which integrate diagnostic molecular imaging and capabilities into a single entity, can be used to monitor treatment process reflect effect. However, current theranostic probes lack precise evaluations vivo due use single-wavelength during tumor therapy. Here we present portal library dual ratiometric single-molecule therapy through photothermal (PTT) cell death via near-infrared fluorescence (NIRF) photoacoustic (PA) imaging. One optimal dye further modified an activatable probe (AF-1F-NO2), whose NIRF/PA signal activity are only activated presence biomarker (nitroreductase). By eliciting response (NIRF/PA: NIRF850/NIRF750; PA770/PA670) hypoxia, new acts as hypoxia-activated PTT agent, enabling real-time PTT. Thus, this study not presents first efficacy vivo, but also opens up promising paradigm engineering other combination with more modalities medicine.

Language: Английский

Citations

0