Multifunctional glycyrrhizic acid-loaded nanoplatform combining ferroptosis induction and HMGB1 blockade for enhanced tumor immunotherapy

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 19, 2025

Inducing ferroptotic cell death has been recognized as a promising approach in cancer therapy. However, ferroptosis can provoke tumor infiltration by myeloid-derived suppressor cells (MDSCs) through HMGB1 secretion, causing suppressive immune response. On the other hand, also occurs due to its non-selective properties, which compromise anti-tumor immunity. To address these challenges, two-pronged is proposed, encompassing selectively triggered and blockade, aimed at eliciting systemic immunity alleviating immunosuppression. Herein, GSH-specific driven nanoplatform composed of uniform FeOOH nanospindles coated with tetrasulfide bond-bridged mesoporous organosilica (DMOS) shell, loaded inhibitor, glycyrrhizic acid (GA). This endowed high glutathione (GSH) depletion efficiency exhibits highly efficient Fe2+ ROS generation capacity, promotes accumulation LPO subsequently induces ferroptosis. Concurrently, inhibition release counteracts immunosuppressive effects within microenvironment. innovative effectively suppresses growth 4T1 tumors notably enhancing therapeutic outcomes checkpoint blockade across experimental data. The collective findings indicate potential reliable strategy for boosting ferroptosis-mediated favorable safety profiles.

Language: Английский

Top-down bioinspired nanotheranostics with AIE luminogens

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 537, P. 216681 - 216681

Published: April 15, 2025

Language: Английский