Salicylic Acid-Mediated Silver Nanoparticle Green Synthesis: Characterization, Enhanced Antimicrobial, and Antibiofilm Efficacy

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 532 - 532

Published: April 18, 2025

Objectives: Silver nanoparticles (AgNPs) were synthesized via an easy and rapid biogenic synthesis approach, utilizing the dual capabilities of salicylic acid as both a reducing capping agent. Methods: The characterization Salicylic Acid-Mediated Nanoparticle (SA-AgNPs) was conducted using variety techniques, including ultraviolet-visible spectroscopy, dynamic light scattering, scanning electron microscopy combined with energy dispersive X-ray transmission microscopy, diffraction, Fourier transform infrared well thermogravimetric analysis paired differential calorimetry. Results: SA-AgNPs demonstrated significant antibacterial properties against Gram-positive (methicillin-resistant Staphylococcus epidermidis, aureus, Cutibacterium acnes, methicillin-resistant aureus) Gram-negative (Escherichia coli), minimum inhibitory concentrations (MICs) 8, 9, 4, 6 μg/mL, respectively. At concentration 32 exhibited 99.9% killing efficiency Escherichia coli (E. acnes (C. acnes), aureus (MRSA), within 16, 12 h, same concentration, effectively inhibited 95.61% MRSA biofilm formation. induced leakage intracellular macromolecular substances by increasing membrane permeability, which ultimately caused bacterial apoptosis. Conclusions: Overall, this study presents fast environmentally friendly approach for synthesizing SA-AgNPs, potential applications nano antibiotics coatings implantable medical devices wound dressings.

Language: Английский

Defect‐Rich MoO_3‐X@CuO₂ Nanosheets Mediated Ultrasound‐Enhanced Cuproptosis Antibacterial Activity and M2 Macrophage Reprogramming for Optimizing Diabetic Wound Repairment

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Abstract Diabetic wounds are often plagued by persistent bacterial infections, which exacerbate inflammation and impair healing processes such as collagen deposition fibroblast migration. Conventional antibiotic therapies frequently prove ineffective can even hinder wound repair. To address these challenges, biodegradable MoO 3‐x @CuO 2 ion disruptors (MCO IDs) that for comprehensive diabetic treatment is developed. The MCO IDs generate a burst of multimodal reactive oxygen species (ROS) effectively penetrate defenses disrupt redox homeostasis. Released copper ions induce proteotoxic stress‐like death targeting lipoylated iron–sulfur cluster proteins. Transcriptomic metabolomic analyses reveal this mechanism systematically inhibits energy metabolism gene expression, suppressing proliferation. Following eradication, the released promote macrophage repolarization to M2 phenotype, mitigating chronic stimulating healing. Furthermore, enhance management, portable dressing (PVA‐MCO) fabricated electrospinning polyvinyl alcohol (PVA) incorporating IDs. In vivo studies demonstrate PVA‐MCO eliminates pathogenic bacteria promotes deposition, angiogenesis, epithelialization, thereby accelerating This multifaceted therapeutic strategy offers promising solution managing infections promoting

Language: Английский