Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 29, 2025

Comprehensive Summary The site‐selective C–H thiocyanation of quinoline has potential application value but remains undeveloped. We report herein an electrochemical C3‐thiocyanation derivatives under external oxidant‐free conditions. key to success for this reaction is the in situ formation activated silylquinolinium salts. This method exhibits mild conditions, broad substrate scope, and excellent site‐selectivity. practicality protocol further demonstrated by a scale‐up reaction, follow‐up transformations, late‐stage quinoline‐based bioactive molecules.

Language: Английский