Unraveling the Excited-State Dynamics of Er3+ in LiErF4-Based Upconversion Nanoparticles DOI
Shuo Zhang, Xiaoke Hu, Ping Huang

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Lanthanide (Ln3+)-enriched upconversion nanoparticles (UCNPs) with high dopant concentrations have garnered significant attention due to their unique optical properties. However, practical applications are hindered by the deleterious concentration quenching effect. Herein, through kinetic modeling of Er3+ excited-state dynamics employing energy diffusion theories, we demonstrate that in LiErF4 UCNPs predominantly originates from long-range migration 4I13/2 level toward surface and lattice defects, rather than conventionally attributed cross-relaxation mechanism. Such migration-mediated dissipation can be effectively suppressed synergistic engineering strategies combining passivation, spatial confinement via a sandwiched LiYF4@LiErF4@LiYF4 core-shell-shell architecture restrict migration, incorporation Tm3+ as trapping centers, boosting quantum yield <0.01% 2.29% (980 nm@70 W cm-2). The established mechanistic framework material design principles provide critical insights for heavily doped UCNPs, particularly advancing application potential single-particle spectroscopy optoelectronic nanodevices.

Language: Английский

A new class of NIR-II luminescent nanoprobes via Ho3+ sensitization for deep-tissue multiplexed imaging DOI
Yitong Shi, Dengfeng Yang, Wei Zheng

et al.

Chinese Journal of Structural Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 100593 - 100593

Published: March 1, 2025

Language: Английский

Citations

0
Second Near‐Infrared Window Fluorescence Materials for In Vivo Dynamic Multiplexed Imaging DOI
Fang Fan, Kai Zeng, Yingying Zhu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract Second near‐infrared (NIR‐II) fluorescence imaging has emerged as a breakthrough technology for accurately revealing complex mechanisms in vivo owing to its high sensitivity, deeper tissue penetration, spatiotemporal resolution, and throughput. This review provides comprehensive overview of NIR‐II imaging, specifically focusing on the materials used, including single‐walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare‐earth nanoparticles (RENPs), organic fluorophores (OFs). It details their development, application, advantageous performance imaging. Furthermore, this highlights an approach dynamic multiplexed that enables multitarget detection, providing powerful tool effectively assessing pathological processes biological vivo. Finally, it explores aspects translational medicine addressing challenges, future prospects related material detection equipment, unmet biomedical applications.

Language: Английский

Citations

0
Renal-Clearable Molecular Reporters for Near-Infrared Fluorescence Imaging and Urinalysis of Pulmonary Metastatic Tumor DOI

Ya Zhou,

Jun Chen, Yang Zhou

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Despite approximately 40% of all patients with cancer developing pulmonary metastases in the course their disease, it remains a diagnostic challenge clinical practice. Herein, we propose fluorogenic probe (CPRG) gamma-glutamyl transferase (GGT)-triggered signal turn-on for near-infrared fluorescence imaging (NIRF) and urinalysis orthotopic metastatic tumors living mice. CPRG comprised four key moieties: GGT-reactive moiety, hemicyanine-based unit, polyethylene glycol linker, an active tumor targeting moiety. Such tailored is intrinsically nonfluorescent only activates its NIRF signals presence GGT. After intratracheal administration into lungs tumor-bearing mice, can efficiently accumulate sensitively real-time imaging. Relying on high renal clearance efficiency (∼70% ID), be rapidly excreted through kidneys assessed by chemotherapeutic efficacy cisplatin. This study not reports tracers but also provides guidelines development molecular probes companion diagnosis cancer.

Language: Английский

Citations

0
Unraveling the Excited-State Dynamics of Er3+ in LiErF4-Based Upconversion Nanoparticles DOI
Shuo Zhang, Xiaoke Hu, Ping Huang

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Lanthanide (Ln3+)-enriched upconversion nanoparticles (UCNPs) with high dopant concentrations have garnered significant attention due to their unique optical properties. However, practical applications are hindered by the deleterious concentration quenching effect. Herein, through kinetic modeling of Er3+ excited-state dynamics employing energy diffusion theories, we demonstrate that in LiErF4 UCNPs predominantly originates from long-range migration 4I13/2 level toward surface and lattice defects, rather than conventionally attributed cross-relaxation mechanism. Such migration-mediated dissipation can be effectively suppressed synergistic engineering strategies combining passivation, spatial confinement via a sandwiched LiYF4@LiErF4@LiYF4 core-shell-shell architecture restrict migration, incorporation Tm3+ as trapping centers, boosting quantum yield <0.01% 2.29% (980 nm@70 W cm-2). The established mechanistic framework material design principles provide critical insights for heavily doped UCNPs, particularly advancing application potential single-particle spectroscopy optoelectronic nanodevices.

Language: Английский

Citations

0