Multifunctional Mesoporous Silicon Nanoparticles for MRI-Based Diagnostic Imaging and Glioma Therapy DOI

Huiru Zhu,

Xiaoying Ni, Jiaxin Su

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

To overcome the limited efficacy of chemodynamic therapy (CDT) caused by insufficient hydrogen peroxide (H2O2) in tumor microenvironment, we engineered a glutathione (GSH)-responsive multifunctional nanosystem, HCTG-C, based on hollow mesoporous organosilica nanoparticles. This system integrates tirapazamine (TPZ), glucose oxidase (GOx), situ-synthesized copper sulfide (CuS), and CT2A glioma cell membrane coating to enable dual tumor-targeted self-imaging capabilities. The therapeutic mechanism relies three synergistic cascades: (1) GOx-mediated oxidation deplete oxygen generate H2O2, establishing self-sustaining H2O2 supply; (2) GSH-triggered CuS conversion Cu(I), amplifying Fenton-like reactions for efficient H2O2-to-reactive species ferroptosis induction; (3) hypoxia-activated TPZ exert cytotoxic effects, synergizing chemotherapy with CDT. Experimental results demonstrated that HCTG-C achieves real-time MRI monitoring via GSH depletion-driven Cu valence transitions, while its self-replenishing oxygen-activation mechanisms significantly enhance antitumor against vitro vivo. By innovatively combining self-supply cascades, chemotherapy, ferroptosis-driven CDT, this work presents paradigm-shifting strategy self-imaging-guided combinatorial therapy, advancing ferroptosis-based approaches precision treatment.

Language: Английский

Multifunctional Mesoporous Silicon Nanoparticles for MRI-Based Diagnostic Imaging and Glioma Therapy DOI

Huiru Zhu,

Xiaoying Ni, Jiaxin Su

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

To overcome the limited efficacy of chemodynamic therapy (CDT) caused by insufficient hydrogen peroxide (H2O2) in tumor microenvironment, we engineered a glutathione (GSH)-responsive multifunctional nanosystem, HCTG-C, based on hollow mesoporous organosilica nanoparticles. This system integrates tirapazamine (TPZ), glucose oxidase (GOx), situ-synthesized copper sulfide (CuS), and CT2A glioma cell membrane coating to enable dual tumor-targeted self-imaging capabilities. The therapeutic mechanism relies three synergistic cascades: (1) GOx-mediated oxidation deplete oxygen generate H2O2, establishing self-sustaining H2O2 supply; (2) GSH-triggered CuS conversion Cu(I), amplifying Fenton-like reactions for efficient H2O2-to-reactive species ferroptosis induction; (3) hypoxia-activated TPZ exert cytotoxic effects, synergizing chemotherapy with CDT. Experimental results demonstrated that HCTG-C achieves real-time MRI monitoring via GSH depletion-driven Cu valence transitions, while its self-replenishing oxygen-activation mechanisms significantly enhance antitumor against vitro vivo. By innovatively combining self-supply cascades, chemotherapy, ferroptosis-driven CDT, this work presents paradigm-shifting strategy self-imaging-guided combinatorial therapy, advancing ferroptosis-based approaches precision treatment.

Language: Английский

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