Crystallization of Small Molecules in Microgravity Using Pharmaceutical In-Space Laboratory–Biocrystal Optimization eXperiment (PIL-BOX) DOI Creative Commons

Ladonna Miller,

Molly K. Mulligan,

Kenneth A. Savin

et al.

Crystals, Journal Year: 2025, Volume and Issue: 15(6), P. 527 - 527

Published: May 30, 2025

Crystallization in microgravity has measurable benefits, from molecules as simple sodium chloride to elaborate protein complexes. However, small organic have not been reported. The glycine, famoxadone, carbamazepine, and 5-methyl-2-((2-nitrophenyl)amino)thiophene-3-carbonitrile (ROY) were crystallized on Earth under conditions. When comparing these different gravity crystallization conditions, we found the formation of polymorphs and/or habits for ROY. famoxadone occurred more slowly microgravity. differences size, appearance, and, case ROY, color, are detailed this report.

Language: Английский

Crystallization of Small Molecules in Microgravity Using Pharmaceutical In-Space Laboratory–Biocrystal Optimization eXperiment (PIL-BOX) DOI Creative Commons

Ladonna Miller,

Molly K. Mulligan,

Kenneth A. Savin

et al.

Crystals, Journal Year: 2025, Volume and Issue: 15(6), P. 527 - 527

Published: May 30, 2025

Crystallization in microgravity has measurable benefits, from molecules as simple sodium chloride to elaborate protein complexes. However, small organic have not been reported. The glycine, famoxadone, carbamazepine, and 5-methyl-2-((2-nitrophenyl)amino)thiophene-3-carbonitrile (ROY) were crystallized on Earth under conditions. When comparing these different gravity crystallization conditions, we found the formation of polymorphs and/or habits for ROY. famoxadone occurred more slowly microgravity. differences size, appearance, and, case ROY, color, are detailed this report.

Language: Английский

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