Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Comprehensive Summary Herein, a highly enantioselective formal synthesis of (+)‐Treprostinil via the interphenylene prostaglandin E 1 scaffold was described. The chiral multi‐substituted cyclopentanone constructed [Rh(Duanphos)SbF 6 ‐catalyzed asymmetric enyne cycloisomerization and copper hydride‐mediated conjugate reduction. In addition, new type obtained Alder‐ene reaction in high yield with excellent chemoselectivity.

Language: Английский