Nickel-Catalyzed Reductive Coupling of 2-Pyridyl Esters with Unreactivated Alkyl Chlorides: A Universal Synthesis of Aryl-Alkyl and Dialkyl Ketones via Dynamic Halide Exchange DOI
Cong Guo, Zhenying Wang,

Wen-Heng Liu

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A Ni-catalyzed reductive coupling of 2-pyridyl esters with unactivated primary and secondary alkyl chlorides provides direct access to aryl–alkyl dialkyl ketones. High selectivity can be achieved by rate-matching via dynamic halide exchange.

Language: Английский

Nickel-Catalyzed Reductive Coupling of 2-Pyridyl Esters with Unreactivated Alkyl Chlorides: A Universal Synthesis of Aryl-Alkyl and Dialkyl Ketones via Dynamic Halide Exchange DOI
Cong Guo, Zhenying Wang,

Wen-Heng Liu

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A Ni-catalyzed reductive coupling of 2-pyridyl esters with unactivated primary and secondary alkyl chlorides provides direct access to aryl–alkyl dialkyl ketones. High selectivity can be achieved by rate-matching via dynamic halide exchange.

Language: Английский

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