Chemistry - A European Journal,
Journal Year:
2016,
Volume and Issue:
23(9), P. 2225 - 2230
Published: Dec. 9, 2016
Medium-sized
rings
are
widely
considered
to
be
under-represented
in
biological
screening
libraries
for
lead
identification
medicinal
chemistry.
To
help
address
this,
a
library
of
medium-sized
lactams
has
been
generated
by
using
simple,
scalable
and
versatile
ring-expansion
protocol.
Analysis
the
open-access
computational
tool
LLAMA
suggested
that
these
their
derivatives
have
highly
promising
physicochemical
3D
spatial
properties
thus
much
potential
drug
discovery.
Chemical Reviews,
Journal Year:
2018,
Volume and Issue:
119(3), P. 1855 - 1969
Published: Dec. 24, 2018
In
this
review,
we
summarize
the
origin
and
advancements
of
iridium-catalyzed
asymmetric
allylic
substitution
reactions
during
past
two
decades.
Since
first
report
in
1997,
Ir-catalyzed
have
attracted
intense
attention
due
to
their
exceptionally
high
regio-
enantioselectivities.
been
significantly
developed
recent
years
many
respects,
including
ligand
development,
mechanistic
understanding,
substrate
scope,
application
synthesis
complex
functional
molecules.
an
explicit
outline
ligands,
mechanism,
scope
nucleophiles,
applications
is
presented.
Angewandte Chemie International Edition,
Journal Year:
2017,
Volume and Issue:
56(11), P. 2927 - 2931
Published: Feb. 6, 2017
Abstract
The
first
catalytic
formal
[5+4]
cycloaddition
to
prepare
nine‐membered
heterocycles
is
presented.
Under
palladium
catalysis,
the
reaction
of
N‐tosyl
azadienes
and
substituted
vinylethylene
carbonates
(VECs)
proceeds
smoothly
produce
benzofuran‐fused
in
uniformly
high
efficiency.
Highly
diastereoselective
functionalization
through
peripheral
attack
also
demonstrated.
Organic & Biomolecular Chemistry,
Journal Year:
2017,
Volume and Issue:
15(17), P. 3550 - 3567
Published: Jan. 1, 2017
Numerous
efficient
synthetic
methods
for
enantioselective
indole
functionalizations
have
emerged
in
recent
years.
This
review
summarizes
the
major
achievements
transition-metal-catalyzed
functionalization
reactions
since
2010
and
focuses
on
C-C
bond
formation
processes,
including
alkylations,
arylations,
cycloaddition
reactions,
other
reactions.
It
intends
to
give
a
compendious
overview
of
significant
progress
achieved
this
area.
Journal of the American Chemical Society,
Journal Year:
2017,
Volume and Issue:
139(43), P. 15304 - 15307
Published: Oct. 17, 2017
The
first
enantioselective
formal
[5+4]
cycloaddition
is
realized
under
palladium
catalysis
to
deliver
benzofuran-fused
nine-membered
rings.
These
medium-sized
heterocycles
and
derivatives
undergo
unique
rearrangements
induced
by
transannular
bond
formation,
resulting
in
the
production
of
two
classes
densely
substituted
polycyclic
excellent
efficiency
stereoselectivity.
Chemistry - A European Journal,
Journal Year:
2017,
Volume and Issue:
23(37), P. 8780 - 8799
Published: March 15, 2017
Functionalised
macrocycles
and
medium-sized
rings
have
applications
in
a
number
of
scientific
fields,
ranging
from
medicinal
chemistry
supramolecular
chemistry,
to
catalysis
nanotechnology.
However,
their
value
these
areas
can
be
undermined
by
simple,
but
important
limitation:
large
ring
systems
are
very
often
difficult
make.
Traditional
end-to-end
cyclisation
reactions
long
linear
precursors
typically
unpredictable
impractical
processes,
mainly
due
unfavourable
enthalpic
entropic
factors.
Most
published
methods
make
focus
on
minimising
the
damage
inflicted
performing
step;
contrast,
ring-expansion
enable
it
avoided
altogether.
In
this
Review
article,
is
highlighted
how
"growing"
existing
cyclic
via
expansion
expedite
efficient,
practical
scalable
synthesis
rings.
Journal of the American Chemical Society,
Journal Year:
2018,
Volume and Issue:
140(10), P. 3551 - 3554
Published: Feb. 22, 2018
The
highly
enantioselective
[5
+
2]
annulation
of
enals
with
vinylethylene
carbonates
through
a
cooperative
N-heterocyclic
carbene
(NHC)/Pd
catalytic
system
is
reported.
use
bidentate
phosphine
ligand
was
crucial
to
prevent
coordination
the
NHC
organocatalyst
active
Pd
catalyst.
complementary
and
matched
combination
chiral
catalyst
promotes
high
levels
both
reactivity
enantioselectivity
(mostly
≥99%
ee).
ACS Catalysis,
Journal Year:
2016,
Volume and Issue:
6(8), P. 4814 - 4858
Published: June 9, 2016
Chiral
monophosphorus
ligands
are
playing
an
important
role
for
the
recent
advances
in
asymmetric
catalysis.
This
review
summarizes
latest
progress
various
catalytic
reactions
with
employment
of
chiral
including
allylic
substitution,
dearomative
arylation,
Heck
reaction,
cross-coupling,
C–H
bond
functionalization,
coupling
π
systems,
addition,
hydrogenation,
and
organocatalytic
reactions.
The
new
reactivity,
selectivity,
reaction
mechanism
enabled
by
these
discussed.
Angewandte Chemie International Edition,
Journal Year:
2017,
Volume and Issue:
57(6), P. 1596 - 1600
Published: Dec. 19, 2017
Abstract
We
report
herein
the
first
enantioselective
cycloaddition
of
vinyl
oxetanes,
reaction
which
with
azadienes
provided
unprecedented
access
to
ten‐membered
heterocycles
through
a
[6+4]
cycloaddition.
By
using
commercially
available
chiral
Pd‐SIPHOX
catalyst,
wide
range
benzofuran‐
as
well
indole‐fused
could
be
accessed
in
excellent
yield
and
enantioselectivity.
A
unique
Lewis
acid
induced
fragmentation
these
was
also
discovered.
Journal of the American Chemical Society,
Journal Year:
2016,
Volume and Issue:
138(40), P. 13103 - 13106
Published: Sept. 19, 2016
Here
we
report
an
iridium-catalyzed
asymmetric
umpolung
allylation
of
imines
as
a
general
approach
to
prepare
1,4-disubstituted
homoallylic
amines,
fundamental
class
compounds
that
are
hitherto
not
straightforward
obtain.
This
transformation
proceeds
by
cascade
involving
intermolecular
regioselective
2-azaallyl
anions
and
following
2-aza-Cope
rearrangement,
utilizes
easily
available
reagents
catalysts,
tolerates
substantial
scope
substrates,
readily
leads
various
enantioenriched,
primary
amines.
