Organic Letters,
Journal Year:
2018,
Volume and Issue:
20(15), P. 4579 - 4583
Published: July 19, 2018
An
efficient
and
mild
zinc-mediated
decarboxylative
alkylation
of
gem-difluoroalkenes
with
N-hydroxyphthalimide
(NHP)
esters,
to
give
monofluoroalkenes
in
moderate
excellent
yields
high
Z-selectivity
is
reported.
The
reaction
tolerates
a
broad
range
functional
groups
can
be
easily
scaled
up,
which
thus
may
pave
the
way
for
its
further
applications
medicinal
chemistry
materials
science.
Organic Letters,
Journal Year:
2017,
Volume and Issue:
19(19), P. 5348 - 5351
Published: Sept. 19, 2017
Cobaltacycle
synthesis
via
C-H
activation
has
been
achieved
for
the
first
time,
providing
key
mechanistic
insight
into
cobalt
catalytic
chemistry.
N-Chloroamides
are
used
as
a
directing
synthon
cobalt-catalyzed
room-temperature
and
construction
of
heterocycles.
Alkynes
coupling
partners
allow
convenient
access
to
isoquinolones,
class
synthetically
pharmaceutically
important
compounds.
The
broad
substrate
scope
enables
diverse
range
substitution
patterns
be
incorporated
heterocyclic
scaffold.
Organic Letters,
Journal Year:
2018,
Volume and Issue:
20(7), P. 1924 - 1927
Published: March 19, 2018
A
reductive
cross-coupling
of
gem-difluoroalkenes
with
diverse
unactivated
and
heteroatom
substituted
olefins
through
a
Fe-catalyzed
hydrogen
atom
transfer
(HAT)
strategy
is
reported.
Different
from
the
previous
HAT-type
olefin
reactions,
presence
fluorine
in
molecule
results
stereoselective
β-F
cleavage,
leading
to
C(sp2)–C(sp3)
bond
formation.
wide
variety
alkylated
monofluoroalkenes
were
obtained
good
efficiency
excellent
Z
selectivity
under
air-
water-tolerant
reaction
conditions.
similar
defluorinative
coupling
was
also
realized.
ACS Catalysis,
Journal Year:
2018,
Volume and Issue:
8(10), P. 9508 - 9519
Published: Sept. 5, 2018
By
virtue
of
a
synergistically
dual-directing-group
(the
O–NHAc
part
and
the
hydroxyl
group)-assisted
strategy,
efficient
practical
Rh(III)-catalyzed
regioselective
redox-neutral
C–H
functionalization
diverse
N-phenoxyacetamides
with
propargyl
alcohols
has
been
realized,
which
led
to
divergent
synthesis
privileged
benzofuran
chalcone
frameworks
in
solvent-controlled
chemoselective
manner.
Experimental
computational
studies
reveal
that
formation
hydrogen
bonding
between
dual
directing
groups
subsequent
coordination
interaction
group
Rh(III)
catalyst
play
decisive
role
promoting
migratory
insertion
alkyne
moiety.
Thereafter,
two
switchable
reaction
pathways,
respectively
involve
tandem
β–H
elimination/hydrogen
transfer/oxidative
addition/C–O
bond
reductive
elimination/oxidation
(for
low-polar
solvents:
path
I–Ia
via
RhIII–RhI–RhIII
pathway)
oxidative
addition/β–H
transfer/protonolysis
high-polar
II–IIb
RhIII–RhV–RhIII
pathway),
are
followed
deliver
corresponding
products
excellent
chemoselectivity.
Taken
together,
our
results
presented
here
not
only
give
an
expansion
area
O–NHAc-directed
activations
but
also
provide
rational
basis
for
future
development
synergistic
DGs-enabled
reactions.
Organic Letters,
Journal Year:
2018,
Volume and Issue:
20(15), P. 4579 - 4583
Published: July 19, 2018
An
efficient
and
mild
zinc-mediated
decarboxylative
alkylation
of
gem-difluoroalkenes
with
N-hydroxyphthalimide
(NHP)
esters,
to
give
monofluoroalkenes
in
moderate
excellent
yields
high
Z-selectivity
is
reported.
The
reaction
tolerates
a
broad
range
functional
groups
can
be
easily
scaled
up,
which
thus
may
pave
the
way
for
its
further
applications
medicinal
chemistry
materials
science.
