ACS Catalysis,
Journal Year:
2018,
Volume and Issue:
8(5), P. 3820 - 3824
Published: March 9, 2018
A
ruthenium-catalyzed
electrochemical
dehydrogenative
annulation
reaction
of
aniline
derivatives
and
alkynes
has
been
developed
for
the
synthesis
indoles.
Electric
current
is
used
to
recycle
active
ruthenium-based
catalyst
promote
H2
evolution.
The
electrolysis
operationally
convenient
as
it
employs
a
simple
undivided
cell,
proceeds
efficiently
in
an
aqueous
solution,
insensitive
air.
Angewandte Chemie International Edition,
Journal Year:
2018,
Volume and Issue:
57(9), P. 2383 - 2387
Published: Jan. 10, 2018
Electrochemistry
enabled
C-H/N-H
functionalizations
at
room
temperature
by
external
oxidant-free
cobalt
catalysis.
Thus,
the
sustainable
electrocatalysis
manifold
proceeds
with
excellent
levels
of
chemoselectivity
and
positional
selectivity,
ample
scope,
thus
allowing
electrochemical
C-H
activation
under
exceedingly
mild
reaction
conditions
in
water.
Journal of the American Chemical Society,
Journal Year:
2018,
Volume and Issue:
140(25), P. 7913 - 7921
Published: May 29, 2018
Electrochemical
oxidative
C–H/N–H
activations
have
been
accomplished
with
a
versatile
cobalt
catalyst
in
terms
of
[4
+
2]
annulations
internal
alkynes.
The
electro-oxidative
C–H
activation
manifold
proved
viable
an
undivided
cell
setup
under
exceedingly
mild
reaction
conditions
at
room
temperature
using
earth-abundant
catalysts.
electrochemical
catalysis
prevents
the
use
transition
metal
oxidants
catalysis,
generating
H2
as
sole
byproduct.
Detailed
mechanistic
studies
provided
strong
support
for
facile
cobaltation
by
initially
formed
cobalt(III)
catalyst.
subsequent
alkyne
migratory
insertion
was
interrogated
mass
spectrometry
and
DFT
calculations,
providing
formation
key
seven-membered
cobalta(III)
cycle
regioselective
fashion.
Key
to
success
unprecedented
alkynes
represented
N-2-pyridylhydrazides,
which
we
developed
traceless
electrocleavage
strategy
electroreductive
samarium
temperature.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(32), P. 13451 - 13457
Published: April 3, 2020
Abstract
Asymmetric
pallada‐electrocatalyzed
C−H
olefinations
were
achieved
through
the
synergistic
cooperation
with
transient
directing
groups.
The
electrochemical,
atroposelective
activations
realized
high
position‐,
diastereo‐,
and
enantio‐control
under
mild
reaction
conditions
to
obtain
highly
enantiomerically‐enriched
biaryls
fluorinated
N−C
axially
chiral
scaffolds.
Our
strategy
provided
expedient
access
to,
among
others,
novel
BINOLs,
dicarboxylic
acids
helicenes
of
value
asymmetric
catalysis.
Mechanistic
studies
by
experiments
computation
key
insights
into
catalyst's
mode
action.
ACS Catalysis,
Journal Year:
2018,
Volume and Issue:
8(5), P. 3820 - 3824
Published: March 9, 2018
A
ruthenium-catalyzed
electrochemical
dehydrogenative
annulation
reaction
of
aniline
derivatives
and
alkynes
has
been
developed
for
the
synthesis
indoles.
Electric
current
is
used
to
recycle
active
ruthenium-based
catalyst
promote
H2
evolution.
The
electrolysis
operationally
convenient
as
it
employs
a
simple
undivided
cell,
proceeds
efficiently
in
an
aqueous
solution,
insensitive
air.
