Organic Letters,
Journal Year:
2019,
Volume and Issue:
22(1), P. 164 - 167
Published: Dec. 23, 2019
A
straight
synthetic
approach
to
fused
polycyclic
tropane
scaffold
formation
through
an
asymmetric
dearomatization
cycloaddition
process
of
2-nitrobenzofurans
with
cyclic
azomethine
ylides
was
successfully
developed.
In
the
presence
a
chiral
copper
complex,
derived
from
Cu(OAc)2
and
diphosphine
ligand,
series
derivatives
were
obtained
in
high
yields
(75–91%)
excellent
enantioselectivities
(90–98%).
The
utility
this
method
showcased
by
facile
transformation
product.
Chemical Science,
Journal Year:
2022,
Volume and Issue:
13(9), P. 2686 - 2691
Published: Jan. 1, 2022
A
new
type
of
donor–acceptor
cyclopropane
with
gem
-difluorine
as
an
unconventional
donor
group
undergoes
(3
+
2)-cycloadditions
various
aldehydes/ketones,
affording
densely
functionalized
-difluorotetrahydrofurans.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(17), P. 3163 - 3167
Published: April 25, 2023
The
first
catalytic
asymmetric
cascade
Heck-alkylation
reaction
of
NH2-unprotected
amino
acid
esters
with
N-(2-iodophenyl)allenamides
is
reported
in
this
work.
Under
the
promotion
a
combining
system
comprising
chiral
aldehyde,
palladium
complex,
and
Lewis
ZnCl2,
title
takes
place
smoothly,
giving
optically
active
α-alkyl
tryptophan
derivatives
moderate
to
good
yields
excellent
enantioselectivities.
target
products
can
be
converted
into
other
structurally
complex
indoles
without
loss
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(31)
Published: June 17, 2024
Abstract
Oxazocines
are
key
structural
intermediates
in
the
synthesis
of
natural
products
and
pharmaceutical
molecules.
However,
oxazocines
especially
a
highly
enantioselective
manner,
is
long‐standing
formidable
challenge
due
to
unfavorable
energetics
involved
cyclization.
Herein,
series
new
PNP‐Ligand
P
‐chiral
stereocenter
first
designed
synthesized,
called
MQ‐Phos
,
successfully
applied
it
Pd‐catalyzed
higher‐order
formal
[4+4]‐cycloaddition
α
β
‐unsaturated
imines
with
2‐(hydroxymethyl)‐1‐arylallyl
carbonates.
The
reaction
features
mild
conditions,
excellent
regio‐
enantiocontrol
broad
substrate
scope
(54
examples).
Various
medium‐sized
rings
can
be
afforded
moderate
yields
(up
92%)
enantioselectivity
99%
ee).
newly
developed
critical
for
ring
catalytic
reactivity
enantioselectivity.
Chemical Communications,
Journal Year:
2019,
Volume and Issue:
55(62), P. 9144 - 9147
Published: Jan. 1, 2019
The
phosphine-catalyzed
asymmetric
dearomative
[3+2]
cycloaddition
of
2-nitrobenzofurans
with
aldehyde-derived
Morita-Baylis-Hillman
(MBH)
carbonates
or
allenoate
was
developed.
reaction
MBH
resulted
in
a
series
cyclopentabenzofurans
containing
three
contiguous
stereocenters
good
to
high
yields,
diastereoselectivities
and
enantioselectivities.
use
also
gave
the
target
product
moderate
enantioselectivity.
Organic Letters,
Journal Year:
2019,
Volume and Issue:
22(1), P. 164 - 167
Published: Dec. 23, 2019
A
straight
synthetic
approach
to
fused
polycyclic
tropane
scaffold
formation
through
an
asymmetric
dearomatization
cycloaddition
process
of
2-nitrobenzofurans
with
cyclic
azomethine
ylides
was
successfully
developed.
In
the
presence
a
chiral
copper
complex,
derived
from
Cu(OAc)2
and
diphosphine
ligand,
series
derivatives
were
obtained
in
high
yields
(75–91%)
excellent
enantioselectivities
(90–98%).
The
utility
this
method
showcased
by
facile
transformation
product.
