Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(38)
Published: July 26, 2021
Abstract
Chiral
plasmonic
nanomaterials
have
attracted
unprecedented
attention
due
to
their
broad
applications
in
biomedicine,
negative
refractive
index,
and
chiral
sensing.
Here,
using
a
wet‐chemistry
process,
triangular
Au
nanorings
are
fabricated
with
platinum
(Pt)
framework
(
l
/
d
‐Pt@Au
nanorings,
named
TNRs).
The
TNRs
exhibit
strong
optical
activity
g
‐factor
of
0.023
can
be
used
effectively
for
the
discrimination
enantiomers
selective
resonance
coupling
between
induced
electric
magnetic
dipoles
associated
TNRs,
also
known
as
surface‐enhanced
Raman
scattering‐chiral
anisotropy
(SERS‐ChA)
effect.
represent
label‐free
SERS
platform
that
applied
detect
Aβ
monomers
fibrils,
hallmarks
Alzheimer's
disease
(AD),
achieving
limit
detection
(LOD)
down
0.045
×
10
−12
m
4
−15
42‐residue‐long
amyloid‐β
(Aβ
42
)
monomer
respectively.
Furthermore,
successfully
carried
out
proteins
AD
patients
ultrahigh
levels
sensitivity,
thus
allowing
picogram
quantities
identified.
This
research
opens
up
an
avenue
use
ultrasensitive
substrates
early
diagnosis
protein‐misfolding
diseases.
Chemical Reviews,
Journal Year:
2019,
Volume and Issue:
119(6), P. 4357 - 4412
Published: Feb. 25, 2019
Because
of
the
high
catalytic
activities
and
substrate
specificity,
natural
enzymes
have
been
widely
used
in
industrial,
medical,
biological
fields,
etc.
Although
promising,
they
often
suffer
from
intrinsic
shortcomings
such
as
cost,
low
operational
stability,
difficulties
recycling.
To
overcome
these
shortcomings,
researchers
devoted
to
exploration
artificial
enzyme
mimics
for
a
long
time.
Since
discovery
ferromagnetic
nanoparticles
with
horseradish
peroxidase-like
activity
2007,
large
amount
studies
on
nanozymes
constantly
emerging
next
decade.
Nanozymes
are
one
kind
nanomaterials
enzymatic
properties.
Compared
enzymes,
advantages
stability
durability,
which
fields.
A
thorough
understanding
possible
mechanisms
will
contribute
development
novel
high-efficient
nanozymes,
rational
regulations
great
significance.
In
this
review,
we
systematically
introduce
classification,
mechanism,
regulation
well
recent
research
progress
field
biosensing,
environmental
protection,
disease
treatments,
past
years.
We
also
propose
current
challenges
their
future
focus.
anticipate
review
may
be
significance
understand
properties
mimicking
activities.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: June 3, 2020
Oxidative
stress
is
associated
with
many
acute
and
chronic
inflammatory
diseases,
yet
limited
treatment
currently
available
clinically.
The
development
of
enzyme-mimicking
nanomaterials
(nanozymes)
good
reactive
oxygen
species
(ROS)
scavenging
ability
biocompatibility
a
promising
way
for
the
ROS-related
inflammation.
Herein
we
report
simple
efficient
one-step
ultrasmall
Cu
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: April 13, 2021
Reactive
oxygen
species
(ROS)
are
generated
and
consumed
in
living
organism
for
normal
metabolism.
Paradoxically,
the
overproduction
and/or
mismanagement
of
ROS
have
been
involved
pathogenesis
progression
various
human
diseases.
Here,
we
reported
a
two-dimensional
(2D)
vanadium
carbide
(V2C)
MXene
nanoenzyme
(MXenzyme)
that
can
mimic
up
to
six
naturally-occurring
enzymes,
including
superoxide
dismutase
(SOD),
catalase
(CAT),
peroxidase
(POD),
glutathione
(GPx),
thiol
(TPx)
haloperoxidase
(HPO).
Based
on
these
enzyme-mimicking
properties,
constructed
2D
V2C
MXenzyme
not
only
possesses
high
biocompatibility
but
also
exhibits
robust
vitro
cytoprotection
against
oxidative
stress.
Importantly,
rebuilds
redox
homeostasis
without
perturbing
endogenous
antioxidant
status
relieves
ROS-induced
damage
with
benign
vivo
therapeutic
effects,
as
demonstrated
both
inflammation
neurodegeneration
animal
models.
These
findings
open
an
avenue
enable
use
remedial
nanoplatform
treat
ROS-mediated
inflammatory
neurodegenerative
Journal of Materials Chemistry B,
Journal Year:
2021,
Volume and Issue:
9(35), P. 6939 - 6957
Published: Jan. 1, 2021
This
review
summarizes
catalytic
mechanisms,
regulatory
factors,
measurement
methods
and
various
applications
of
SOD-like
nanozymes,
as
well
proposes
the
current
challenges
prospects
in
development
nanozymes.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
32(14)
Published: Dec. 16, 2021
Abstract
The
manufacture
of
bionic
materials
to
simulate
the
natural
counterparts
has
attracted
extensive
attention.
As
one
subcategories
biomimetic
materials,
development
artificial
enzyme
is
intensive
pursuing.
a
kind
enzyme,
nanozymes
are
dedicated
solve
limitations
enzymes.
In
recent
years,
attributed
explosive
nanotechnology,
biotechnology,
catalysis
science,
computational
design
and
theory
calculation,
research
on
made
great
progress.
To
highlight
these
achievements
help
researchers
understand
current
investigation
status
nanozyme,
state‐of‐the‐art
in
from
fabrication
bioapplications
summarized.
First
different
raw
summarized,
including
metal‐based,
metal‐free,
metal‐organic
frameworks‐based,
some
other
novel
matters,
which
applied
fabricate
nanozymes.
types
enzymes‐like
catalytic
activities
briefly
discussed.
Subsequently,
wide
applications
such
as
anti‐oxidation,
curing
diseases,
anti‐bacteria,
biosensing,
bioimaging
Finally,
challenges
faced
by
outlined
future
directions
for
advancing
nanozyme
outlooked.
authors
hope
this
review
can
inspire
fields
chemistry,
biology,
theoretical
computing,
contribute
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(8)
Published: Jan. 13, 2020
The
intrinsic
deficiencies
of
nanoparticle-initiated
catalysis
for
biomedical
applications
promote
the
fast
development
alternative
versatile
theranostic
modalities.
catalytic
performance
and
selectivity
are
critical
issues
that
challenging
to
be
augmented
optimized
in
biological
conditions.
Single-atom
catalysts
(SACs)
featuring
atomically
dispersed
single
metal
atoms
have
emerged
as
one
most
explored
biomedicine
recently
due
their
preeminent
activity
superior
distinct
from
nanosized
counterparts.
Herein,
an
overview
pivotal
significance
SACs
some
underlying
need
addressed
is
provided,
with
a
specific
focus
on
applications.
Their
fabrication
strategies,
surface
engineering,
structural
characterizations
discussed
briefly.
In
particular,
triggering
representative
reactions
providing
fundamentals
use
discussed.
A
sequence
paradigms
summarized
successful
construction
varied
(e.g.,
cancer
treatment,
wound
disinfection,
biosensing,
oxidative-stress
cytoprotection)
emphasis
uncovering
mechanisms
understanding
structure–performance
relationships.
Finally,
opportunities
challenges
faced
future
SACs-triggered
outlooked.
Archives of Toxicology,
Journal Year:
2024,
Volume and Issue:
98(5), P. 1323 - 1367
Published: March 14, 2024
Abstract
Reactive
oxygen
species
(ROS)
and
reactive
nitrogen
(RNS)
are
well
recognized
for
playing
a
dual
role,
since
they
can
be
either
deleterious
or
beneficial
to
biological
systems.
An
imbalance
between
ROS
production
elimination
is
termed
oxidative
stress,
critical
factor
common
denominator
of
many
chronic
diseases
such
as
cancer,
cardiovascular
diseases,
metabolic
neurological
disorders
(Alzheimer’s
Parkinson’s
diseases),
other
disorders.
To
counteract
the
harmful
effects
ROS,
organisms
have
evolved
complex,
three-line
antioxidant
defense
system.
The
first-line
mechanism
most
efficient
involves
enzymes
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GPx).
This
line
plays
an
irreplaceable
role
in
dismutation
radicals
(O
2
·−
)
hydrogen
peroxide
(H
O
).
removal
by
SOD
prevents
formation
much
more
damaging
peroxynitrite
ONOO
−
+
NO
·
→
maintains
physiologically
relevant
level
nitric
oxide
(NO
),
important
molecule
neurotransmission,
inflammation,
vasodilation.
second-line
pathway
exogenous
diet-derived
small-molecule
antioxidants.
third-line
ensured
repair
oxidized
proteins
biomolecules
variety
enzyme
review
briefly
discusses
endogenous
(mitochondria,
NADPH,
xanthine
oxidase
(XO),
Fenton
reaction)
(e.g.,
smoking,
radiation,
drugs,
pollution)
sources
(superoxide
radical,
peroxide,
hydroxyl
peroxyl
hypochlorous
acid,
peroxynitrite).
Attention
has
been
given
system
provided
SOD,
CAT,
GPx.
chemical
molecular
mechanisms
enzymes,
enzyme-related
(cancer,
cardiovascular,
lung,
metabolic,
GPx4)
cellular
processes
ferroptosis
discussed.
Potential
therapeutic
applications
mimics
recent
progress
metal-based
(copper,
iron,
cobalt,
molybdenum,
cerium)
nonmetal
(carbon)-based
nanomaterials
with
enzyme-like
activities
(nanozymes)
also
Moreover,
attention
action
low-molecular-weight
antioxidants
(vitamin
C
(ascorbate),
vitamin
E
(alpha-tocopherol),
carotenoids
β-carotene,
lycopene,
lutein),
flavonoids
quercetin,
anthocyanins,
epicatechin),
(GSH)),
activation
transcription
factors
Nrf2,
protection
against
diseases.
Given
that
there
discrepancy
preclinical
clinical
studies,
approaches
may
result
greater
pharmacological
success
therapies
subject
discussion.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Feb. 22, 2022
Nanozyme
is
a
series
of
nanomaterials
with
enzyme-mimetic
activities
that
can
proceed
the
catalytic
reactions
natural
enzymes.
In
field
biomedicine,
nanozymes
are
capturing
tremendous
attention
due
to
their
high
stability
and
low
cost.
Enzyme-mimetic
be
regulated
by
multiple
factors,
such
as
chemical
state
metal
ion,
pH,
hydrogen
peroxide
(H2O2),
glutathione
(GSH)
level,
presenting
great
promise
for
biomedical
applications.
Over
past
decade,
multi-functional
have
been
developed
various
To
promote
understandings
development
novel
multifunctional
nanozymes,
we
herein
provide
comprehensive
review
applications
in
field.
Nanozymes
versatile
enzyme-like
properties
briefly
overviewed,
mechanism
application
discussed
future
research.
Finally,
underlying
challenges
prospects
frontier
this
review.
