Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(6)
Published: Jan. 3, 2023
Abstract
Covalent
organic
frameworks
(COFs)
have
attracted
increasing
attention
for
biomedical
applications.
COFs‐based
nanosensitizers
with
uniform
nanoscale
morphology
and
tumor‐specific
curative
effects
are
in
high
demand;
however,
their
synthesis
is
yet
challenging.
In
this
study,
distinct
COF
nanobowls
synthesized
a
controlled
manner
engineered
as
activatable
sonodynamic
activity.
High
crystallinity
ensures
an
ordered
porous
structure
of
the
efficient
loading
small‐molecule
sonosensitizer
rose
bengal
(RB).
To
circumvent
non‐specific
damage
to
normal
tissues,
sonosensitization
effect
specifically
inhibited
by
situ
growth
manganese
oxide
(MnO
x
)
on
RB‐loaded
COFs.
Upon
reaction
tumor‐overexpressed
glutathione
(GSH),
“gatekeeper”
MnO
rapidly
decomposed
recover
reactive
oxygen
species
(ROS)
generation
capability
under
ultrasound
irradiation.
Increased
intracellular
ROS
stress
GSH
consumption
concomitantly
induce
ferroptosis
improve
efficacy.
Additionally,
unconventional
bowl‐shaped
renders
enhanced
tumor
accumulation
retention.
The
combination
therapy
achieves
efficacy
killing
cancer
cells
inhibiting
growth.
This
study
paves
way
development
morphologies
biomedicine,
offering
paradigm
realize
ferroptosis‐augmented
therapy.
Materials Advances,
Journal Year:
2021,
Volume and Issue:
3(2), P. 707 - 733
Published: Nov. 23, 2021
In
this
review,
we
discuss
the
progress
in
preparation
methods
and
diverse
applications
for
covalent
triazine
frameworks,
hypercrosslinked
polymers,
organic
conjugated
microporous
polymers.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(26), P. 11482 - 11498
Published: June 27, 2022
The
practical
utilization
of
covalent
organic
frameworks
(COFs)
with
manipulation
at
the
atomic
and
molecular
scale
often
demands
their
assembly
on
nano-,
meso-,
macroscale
precise
control.
Consequently,
synthetic
approaches
that
establish
ability
to
control
nucleation
growth
COF
crystallites
self-assembly
desired
nanomorphologies
have
drawn
substantial
attention
from
researchers.
On
basis
dimensionality
morphologies,
we
can
categorize
them
into
zero-
(0-D),
one-
(1-D),
two-
(2-D),
three-dimensional
(3-D)
nanomorphologies.
In
this
perspective,
summarize
reported
strategies
enable
nanomorphologies'
size,
shape,
reveal
impact
dimensionalities
in
physicochemical
properties
applications.
aim
is
a
synergistic
optimization
morphological
while
keeping
micro-
or
mesoporosity,
crystallinity,
chemical
functionalities
COFs
perspective.
A
detailed
knowledge
along
way
should
help
us
enrich
performance
variety
applications
like
catalysis,
separation,
sensing,
drug
delivery,
energy
storage,
etc.
We
discussed
interlinking
between
via
transmutation
dimensionalities.
Such
could
lead
variation
during
transition.
Finally,
concept
constructing
superstructures
through
combination
two
more
has
been
explored,
it
bring
up
opportunities
for
developing
next-generation
innovative
materials
multidisciplinary
Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(46), P. 19446 - 19453
Published: Nov. 3, 2021
Development
of
new
porous
materials
as
hosts
to
suppress
the
dissolution
and
shuttle
lithium
polysulfides
is
beneficial
for
constructing
highly
efficient
lithium-sulfur
batteries
(LSBs).
Although
2D
covalent
organic
frameworks
(COFs)
host
exhibit
promising
potential
LSBs,
their
performance
still
not
satisfactory.
Herein,
we
develop
polyimide
COFs
(PI-COF)
with
a
well-defined
lamellar
structure,
which
can
be
exfoliated
into
ultrathin
(∼1.2
nm)
nanosheets
(PI-CONs)
large
size
(∼6
μm)
quantity
(40
mg/batch).
Explored
sulfur
PI-COF
PI-CONs
deliver
high
capacities
(1330
1205
mA
h
g-1
at
0.1
C,
respectively),
excellent
rate
capabilities
(620
503
4
superior
cycling
stability
(96%
capacity
retention
0.2
C
PI-CONs)
by
virtue
synergy
robust
conjugated
strong
oxygen-lithium
interactions,
surpassing
vast
majority
organic/polymeric
battery
cathodes
ever
reported.
Our
finding
demonstrates
that
COF
carbonyl
groups
could
LSBs
electrochemical
performance.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(4), P. 1377 - 1414
Published: Jan. 1, 2022
This
review
summarizes
and
discusses
the
recent
progress
in
porous
organic
polymers
for
diverse
biomedical
applications
such
as
drug
delivery,
biomacromolecule
immobilization,
phototherapy,
biosensing,
bioimaging,
antibacterial
applications.
