Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(25), P. 3707 - 3710
Published: Jan. 1, 2023
Radical
defluorinative
functionalization
of
α-trifluoromethyl
styrenes
represents
an
effective
way
toward
gem-difluoroalkenes.
There
are
general
interests
in
developing
novel
synthetic
protocols
for
with
various
types
radicals.
However,
reports
on
the
preparation
gem-difluoro
allylsulfones
via
S-centered
radical
pathway
limited.
Herein,
we
developed
a
photo/nickel
dual-catalyzed
sulfonylation
that
rapidly
and
reliably
synthesizes
allylsulfones.
The
merit
this
protocol
is
exhibited
by
its
mild
conditions
wide
scope,
thus
providing
strategy
sulfonyl
participating
coupling.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(16), P. 6558 - 6562
Published: Aug. 3, 2021
Reported
herein
is
a
visible-light-induced
sulfonation
of
α-trifluoromethylstyrenes
with
sodium
sulfinates,
which
provides
series
α-trifluoromethyl-β-sulfonyl
tertiary
alcohols.
This
new
synthetic
protocol
enabled
by
charge-transfer
complex
between
oxygen
and
featuring
broad
substrate
scope
scalability.
Excellent
functional
group
compatibility
chemoselectivity
render
this
method
suitable
for
pharmaceutically
relevant
molecules.
In
the
presence
D2O,
deuteriotrifluorinated
products
were
also
obtained,
further
demonstrating
flexibility
potentials
strategy.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(5), P. 1016 - 1022
Published: Jan. 25, 2022
Abstract
An
electrochemical
hydroxysulfonylation
of
α‐CF
3
alkenes
was
accomplished
in
this
work.
By
using
easily
available
sodium
sulfinates
as
the
sulfonylating
agents,
a
series
valuable
α‐trifluoromethyl
tertiary
alcohols
were
synthesized
under
mild
and
environmentally
friendly
electrolysis
conditions
moderate
to
good
yields.
The
preliminary
mechanistic
investigation
indicates
that
difunctional
reaction
involves
radical
process
via
sulfonyl
radical.
Gram‐scale
synthesis
shows
significant
potential
application
protocol.
magnified
image
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(14), P. 2705 - 2710
Published: April 5, 2022
We
report
the
transition-metal-free
defluorinative
C-C
bond-forming
reaction
of
trifluoromethyl
alkenes
with
gem-(diborylalkyl)lithiums.
This
synthetic
strategy
provides
access
to
a
variety
4,4-difluoro
homoallylic
diboronate
esters,
which
serve
as
versatile
intermediates
in
efficient
preparation
valuable
gem-difluoroalkene
derivatives.
Further
modifications
are
conducted
demonstrate
utility
obtained
esters.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(5), P. 2000 - 2010
Published: Jan. 1, 2023
A
highly
tunable
defluorophosphorylation
of
fluorinated
peroxides
for
the
preparation
C
3,4-diphosphoryl
furans
and
4-monophosphoryl
under
conditions
with
no
added
transition
metals
is
disclosed.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(25), P. 3707 - 3710
Published: Jan. 1, 2023
Radical
defluorinative
functionalization
of
α-trifluoromethyl
styrenes
represents
an
effective
way
toward
gem-difluoroalkenes.
There
are
general
interests
in
developing
novel
synthetic
protocols
for
with
various
types
radicals.
However,
reports
on
the
preparation
gem-difluoro
allylsulfones
via
S-centered
radical
pathway
limited.
Herein,
we
developed
a
photo/nickel
dual-catalyzed
sulfonylation
that
rapidly
and
reliably
synthesizes
allylsulfones.
The
merit
this
protocol
is
exhibited
by
its
mild
conditions
wide
scope,
thus
providing
strategy
sulfonyl
participating
coupling.
