Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(15), P. 6287 - 6294
Published: April 4, 2023
Mitochondrial
membrane
potential
(MMP)
and
sulfur
dioxide
(SO2)
significantly
affect
the
mitochondrial
state.
In
this
work,
TC-2
TC-8
were
constructed
through
side-chain
engineering,
in
which
bearing
poorer
hydrophobicity
could
localize
on
mitochondria
better.
Interestingly,
short-wave
emission
was
captured
due
to
sensitive
response
of
SO2
(LOD
=
13.8
nM).
Meanwhile,
probe
bind
with
DNA,
presenting
enhanced
long-wave
emission.
Encouragingly,
migrate
from
nucleus
when
MMP
decreased,
accompanied
by
increase
fluorescence
lifetime
(9-fold).
Hence,
be
used
for
dual-channel
monitoring
MMP,
showed
a
completely
different
pathway
commercial
detectors
JC-1/JC-10.
The
cellular
experiments
that
gradually
decreased
reactive
oxygen
species-triggered
oxidative
stress,
level
up-regulated
simultaneously.
Overall,
work
proposed
new
method
investigate
diagnose
mitochondrial-related
diseases.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(1), P. 217 - 217
Published: Jan. 4, 2021
Recent
advances
in
fluorescence
imaging
techniques
and
super-resolution
microscopy
have
extended
the
applications
of
fluorescent
probes
studying
various
cellular
processes
at
molecular
level.
Specifically,
organelle-targeted
been
commonly
used
to
detect
metabolites
transient
chemical
messengers
with
high
precision
become
invaluable
tools
study
biochemical
pathways.
Moreover,
several
recent
studies
reported
labeling
strategies
novel
scaffolds
enhance
target
specificity
responsiveness.
In
this
review,
we
will
survey
most
reports
assess
their
general
structural
features
on
basis
organelles.
We
discuss
advantages
currently
potential
challenges
application
as
well
future
directions.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 9, 2022
Dissipative
self-assembly,
one
of
fundamentally
important
out-of-equilibrium
self-assembly
systems,
can
serve
as
a
controllable
platform
to
exhibit
temporal
processes
for
various
non-stimulus
responsive
properties.
However,
construction
light-fueled
dissipative
structures
with
transformable
morphology
modulate
non-photoresponsive
properties
remains
great
challenge.
Here,
we
report
light-activated
photodeformable
system
in
aqueous
solution
metastable
fluorescent
palette.
Zwitterionic
sulfonato-merocyanine
is
employed
light-induced
amphiphile
co-assemble
polyethyleneimine
after
light
irradiation.
The
formed
spherical
nanoparticles
spontaneously
transform
into
cuboid
ones
the
dark
simultaneous
variation
particle
sizes.
Then
two
kinds
reversibly
interconvert
each
other
by
periodical
irradiation
and
thermal
relaxation.
Furthermore,
loading
different
fluorophores
exhibiting
red,
green,
blue
emissions
their
mixtures,
all
these
deformable
display
time-dependent
fluorescence
wide
range
colors.
Owing
excellent
performance
assembly
platform,
light-controlled
has
achieved
358-fold
enhancement.
Therefore,
exposing
loaded
spatially
controlled
manner
allows
us
draw
multicolored
images
that
disappeared
specific
period
time.
The Analyst,
Journal Year:
2021,
Volume and Issue:
146(24), P. 7450 - 7463
Published: Jan. 1, 2021
Fluorescent
probes
along
with
fluorescence
microscopy
are
essential
tools
for
biomedical
research.
Various
cellular
ubiquitous
chemical
factors
such
as
pH,
H2O2,
and
Ca2+
labeled
traced
using
specific
fluorescent
probes,
therefore
helping
us
to
explore
their
physiological
function
pathological
change.
Among
them,
intracellular
pH
value
is
an
important
factor
that
governs
biological
processes,
generally
∼7.2.
Furthermore,
organelles
within
cells
possess
unique
acid-base
homeostasis,
involving
the
acidic
lysosomes,
alkalescent
mitochondria,
neutral
endoplasmic
reticulum
Golgi
apparatus,
which
undergo
various
processes
digestion,
ATP
production,
protein
folding
processing.
In
this
review,
recently
reported
targeted
toward
reticulum,
cytoplasm
sensing
change
discussed,
involves
molecular
structures,
behavior,
applications.
