Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(48)
Published: June 24, 2024
Abstract
Sulfilimines
and
their
derivatives
have
garnered
considerable
interest
in
both
synthetic
medicinal
chemistry.
Photochemical
nitrene
transfer
to
sulfides
is
known
as
a
conventional
approach
sulfilimines.
However,
the
existing
methods
limited
substrate
scope
stemming
from
incompatibility
of
singlet
intermediates
with
nucleophilic
functional
groups.
Herein,
we
report
synthesis
N
‐sulfonyl
sulfilimines
via
visible‐light‐mediated
energy
sulfonyl
azides,
uncovering
previously
overlooked
reactivity
triplet
nitrenes
sulfides.
This
reaction
features
broad
group
tolerance,
water
compatibility,
amenability
late‐stage
functionalization
drugs.
Thus,
this
work
represents
an
important
example
chemistry
that
overcomes
challenges
traditional
methods.
Sulfilimines
and
their
derivatives
have
garnered
considerable
interest
in
both
synthetic
medicinal
chemistry.
Photochemical
nitrene
transfer
to
sulfides
is
known
as
a
conventional
approach
sulfilimines.
However,
the
existing
methods
limited
substrate
scope
stemming
from
incompatibility
of
singlet
intermediates
with
nucleophilic
functional
groups.
Herein,
we
report
general
for
synthesis
N-sulfonyl
sulfilimines
enabled
by
visible-light-mediated
energy
sulfonyl
azides,
uncovering
neglected
reactivity
triplet
nitrenes
sulfides.
The
unprecedented
mechanism
involving
single
electron
broad
group
tolerance,
water
compatibility,
amenability
use
late-stage
functionalization
drugs.
Sulfilimines
and
their
derivatives
have
garnered
considerable
interest
in
both
synthetic
medicinal
chemistry.
Photochemical
nitrene
transfer
to
sulfides
is
known
as
a
conventional
approach
sulfilimines.
However,
the
existing
methods
limited
substrate
scope
stemming
from
incompatibility
of
singlet
intermediates
with
nucleophilic
functional
groups.
Herein,
we
report
general
for
synthesis
N-sulfonyl
sulfilimines
enabled
by
visible-light-mediated
energy
sulfonyl
azides,
uncovering
neglected
reactivity
triplet
nitrenes
sulfides.
The
unprecedented
mechanism
involving
single
electron
broad
group
tolerance,
water
compatibility,
amenability
use
late-stage
functionalization
drugs.
RSC Sustainability,
Journal Year:
2024,
Volume and Issue:
2(7), P. 1963 - 1968
Published: Jan. 1, 2024
A
halogen-free
bleaching
of
shellac
was
developed
using
electrochemically
generated
peroxodicarbonate
with
acetonitrile
as
an
activator.
reduced
damage
is
obtained
compared
to
previous
reports.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(48)
Published: June 24, 2024
Abstract
Sulfilimines
and
their
derivatives
have
garnered
considerable
interest
in
both
synthetic
medicinal
chemistry.
Photochemical
nitrene
transfer
to
sulfides
is
known
as
a
conventional
approach
sulfilimines.
However,
the
existing
methods
limited
substrate
scope
stemming
from
incompatibility
of
singlet
intermediates
with
nucleophilic
functional
groups.
Herein,
we
report
synthesis
N
‐sulfonyl
sulfilimines
via
visible‐light‐mediated
energy
sulfonyl
azides,
uncovering
previously
overlooked
reactivity
triplet
nitrenes
sulfides.
This
reaction
features
broad
group
tolerance,
water
compatibility,
amenability
late‐stage
functionalization
drugs.
Thus,
this
work
represents
an
important
example
chemistry
that
overcomes
challenges
traditional
methods.