Novel Copper(II) Coordination Compounds Containing Pyridine Derivatives of N4-Methoxyphenyl-Thiosemicarbazones with Selective Anticancer Activity DOI Creative Commons
Roman Rusnac, Olga Garbuz, Victor Kravtsov

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 6002 - 6002

Published: Dec. 19, 2024

Ten coordination compounds, [Cu(L1)Cl] (C1), [Cu(L1)NO3] (C2), [Cu(L2)Cl] (C3), [Cu(L2)NO3] (C4), [Cu(L3)Cl] (C5), [Cu(L3)NO3] (C6), [Cu(L4)NO3] (C7), [Cu(L4)Cl] (C8), [Cu(L5)Cl] (C9), and [Cu(L5)NO3] (C10), containing pyridine derivatives of N4-methoxyphenyl-thiosemicarbazones were synthesized characterized. The molecular structure four compounds was investigated using single crystal X-ray diffraction. Spectral analysis techniques such as FT-IR, 1H NMR, 13C elemental analysis, molar conductivity used for all the compounds. tested evaluated their anticancer activity selectivity against a variety cancer cell lines, including HL-60, LNCaP, MCF-7, HepG-2, K-562, HeLa, BxPC-3, RD, MDCK normal line. Most demonstrated selective superior to doxorubicin. Notably, ligands showed high antiproliferative HL-60 cells, with IC50 values between 0.01 0.06 µM index 5000. Coordination copper(II) HL1 HL3 notably enhanced activity, lowering 0.03 µM. Additionally, antioxidant these assessed, revealing that most exhibited greater compared Trolox, some showing up 12.3 times higher. Toxicity studies on Daphnia magna indicated low toxicity ligands, generally less than doxorubicin, LC50 ranging from 13 90 µM, suggesting moderate toxicity. Conversely, complexes more toxic, 0.5

Language: Английский

Iron phthalocyanine-catalyzed aerobic oxidation of olefins enabled by metal-hydride hydrogen atom transfer DOI
Yunfei Liu, Kaikai Qiao, Junfeng Yang

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155492 - 155492

Published: Feb. 1, 2025

Language: Английский

Citations

0
Heterogeneous cobalt-complex catalyst for wacker-type oxidation of styrene by balloon O2 DOI

Chengke Chang,

Yuelei Hou,

Jun Li

et al.

Molecular Catalysis, Journal Year: 2025, Volume and Issue: 577, P. 114959 - 114959

Published: March 3, 2025

Language: Английский

Citations

0
Advances in Wacker Oxidation: From Palladium to First-Row Transition Metal Catalysts DOI

Jisna Jose,

Elizabeth J. Diana, Thomas Mathew

et al.

Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123625 - 123625

Published: March 1, 2025

Language: Английский

Citations

0
Cobalt‐Catalyzed Wacker‐Type Aerobic Oxidation of Olefins into Ketones Enabled by PMHS: Giving Value to a Chemical Waste with Optimal Atom‐Economy DOI Creative Commons

Naba Abuhafez,

Rafael Gramage‐Doria

ChemCatChem, Journal Year: 2024, Volume and Issue: 16(16)

Published: April 2, 2024

Abstract Herein, it is demonstrated that a chemical waste from the silicon industry, namely polymethylhydrosiloxane (PMHS), suitable hydrosilane source for challenging, selective aerobic oxidation of olefins into methyl ketones under cobalt catalysis: first row, abundant in Earth's crust and cheap metal with low toxicity. The catalytic system operates unprecedented, stoichiometric amounts while catalyst loading kept at very 1 mol% reactions being finished less than hour high turnover numbers (1,340) record‐breaking frequency values up to 530 h −1 . Mechanistic studies highlight key role porphyrin ligand stabilizing active species does follow radical‐based reaction pathway these particular conditions. These results are relevant replacing expensive scarce palladium catalyst, traditionally used Wacker‐type oxidations, by first‐row, Earth‐abundant transition metals green conditions including efficient valorization such as PMHS.

Language: Английский

Citations

3
Wacker-type oxidation of styrenes with Markovnikov selectivity using copper as a site-selective sequential photooxidant–photoreductant DOI
Youssef Abderrazak, Anurag Chinchole, Oliver Reiser

et al.

Catalysis Science & Technology, Journal Year: 2024, Volume and Issue: 14(14), P. 4068 - 4074

Published: Jan. 1, 2024

Copper acts as a site-selective photooxidant and photoreductant, thus enabling the Wacker-type oxidation of styrenes to acetophenones.

Language: Английский

Citations

3
A sugar-derived ligand for room temperature aerial oxidation or non-aqueous Markovnikov hydration of styrenes using a preformed or in situ generated Co complex DOI

Sachchida Nand Pandey,

Arunava Sengupta,

Rajib Bera

et al.

Catalysis Science & Technology, Journal Year: 2024, Volume and Issue: 14(16), P. 4487 - 4495

Published: Jan. 1, 2024

A novel diaminosugar-salen derived Co( ii ) square-planar complex catalyzes the room temperature, aerial oxidation and non-aqueous hydration of styrenes. DFT studies reveal mechanistic details key ligand features that enable its catalytic ability.

Language: Английский

Citations

1
Novel Copper(II) Coordination Compounds Containing Pyridine Derivatives of N4-Methoxyphenyl-Thiosemicarbazones with Selective Anticancer Activity DOI Creative Commons
Roman Rusnac, Olga Garbuz, Victor Kravtsov

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 6002 - 6002

Published: Dec. 19, 2024

Ten coordination compounds, [Cu(L1)Cl] (C1), [Cu(L1)NO3] (C2), [Cu(L2)Cl] (C3), [Cu(L2)NO3] (C4), [Cu(L3)Cl] (C5), [Cu(L3)NO3] (C6), [Cu(L4)NO3] (C7), [Cu(L4)Cl] (C8), [Cu(L5)Cl] (C9), and [Cu(L5)NO3] (C10), containing pyridine derivatives of N4-methoxyphenyl-thiosemicarbazones were synthesized characterized. The molecular structure four compounds was investigated using single crystal X-ray diffraction. Spectral analysis techniques such as FT-IR, 1H NMR, 13C elemental analysis, molar conductivity used for all the compounds. tested evaluated their anticancer activity selectivity against a variety cancer cell lines, including HL-60, LNCaP, MCF-7, HepG-2, K-562, HeLa, BxPC-3, RD, MDCK normal line. Most demonstrated selective superior to doxorubicin. Notably, ligands showed high antiproliferative HL-60 cells, with IC50 values between 0.01 0.06 µM index 5000. Coordination copper(II) HL1 HL3 notably enhanced activity, lowering 0.03 µM. Additionally, antioxidant these assessed, revealing that most exhibited greater compared Trolox, some showing up 12.3 times higher. Toxicity studies on Daphnia magna indicated low toxicity ligands, generally less than doxorubicin, LC50 ranging from 13 90 µM, suggesting moderate toxicity. Conversely, complexes more toxic, 0.5

Language: Английский

Citations

0