Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1649 - 1649
Published: Dec. 22, 2024
The maintenance of healthy mitochondria is essential for neuronal survival and relies upon mitochondrial quality control pathways involved in biogenesis, dynamics, autophagy (mitophagy). Mitochondrial dysfunction critically implicated Parkinson’s disease (PD), a brain disorder characterized by the progressive loss dopaminergic neurons substantia nigra. Consequently, impaired may play key role PD pathology. This affirmed work indicating that genes such as PRKN PINK1, which participate multiple processes, harbor PD-associated mutations. Furthermore, complex-I-inhibiting toxins like MPTP rotenone are known to cause Parkinson-like symptoms. At heart alpha-synuclein (αS), small synaptic protein misfolds aggregates form disease’s hallmark Lewy bodies. specific mechanisms through aggregated αS exerts its neurotoxicity still unknown; however, given vital both PD, an understanding how influences be elucidating pathogenesis discovering future therapeutic targets. Here, current knowledge relationship between reviewed, highlighting recent findings regarding effects on autophagy.
Language: Английский