Magnetic Hierarchically Mesoporous UIO-66(Ce/Ti) Core-Shell Nanocomposites for Efficient Enrichment of Phosphopeptides DOI Creative Commons

Jieling Zhang,

Nan Li, Hui Lv

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Hierarchically mesoporous metal-organic frameworks (HMUIO-66(Ce/Ti)) was designed and fabricated firstly by using a relatively rigid hydroxypropyl methylcellulose (HPMC) coupled with poly(ethylene oxide-b-propylene oxide-b-ethylene oxide, P123) as soft template. By introducing the synergistic effect of Hofmeister ions template HPMC P123 into water-rich micelle system, obtained HMUIO-66(Ce/Ti) possessed irregularly architecture wide pore size distribution 8.4 ~ 26.8 nm. Furthermore, robust lysozyme coating layer self-organized on Fe3O4@SiO2 nanoparticles readily mediated heterogeneous nucleation growth MOF nanocrystals to form magnetic hierarchically UIO-66(Ce/Ti) core-shell nanocomposites (MHMUIO-66(Ce/Ti) CSNCs). The MHMUIO-66(Ce/Ti) CSNCs exhibited high BET surface area 471.6 m2·g− 1 large volume 0.39 cm3·g− 1, central 13.7 nm 7.8 24.5 nm, good chemical stability, superparamagnetic properties. Consequently, provided accessibility bimetallic Ce/Ti inside binding sites thus enhanced phosphopeptides enrichment performance low detection limit (0.5 fmol) selectivity (mass ratio β-casein/BSA, 1:1000). successful identification 24 enriched from an actual sample skim milk suggested that this method could be candidate for identifying phosphopeptide biomarkers in more complex biological samples.

Language: Английский

FeMo6 integrated covalent organic frameworks: Peroxidase-mimetic colorimetric biosensors for multivariate sensing hydrogen peroxide and ascorbic acid in serum and beverages DOI
Xinyu Han,

Ji-hong Zhou,

Yunjie Li

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 479, P. 143727 - 143727

Published: March 6, 2025

Language: Английский

Citations

1
Magnetic Hierarchically Mesoporous UIO-66(Ce/Ti) Core-Shell Nanocomposites for Efficient Enrichment of Phosphopeptides DOI Creative Commons

Jieling Zhang,

Nan Li, Hui Lv

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Hierarchically mesoporous metal-organic frameworks (HMUIO-66(Ce/Ti)) was designed and fabricated firstly by using a relatively rigid hydroxypropyl methylcellulose (HPMC) coupled with poly(ethylene oxide-b-propylene oxide-b-ethylene oxide, P123) as soft template. By introducing the synergistic effect of Hofmeister ions template HPMC P123 into water-rich micelle system, obtained HMUIO-66(Ce/Ti) possessed irregularly architecture wide pore size distribution 8.4 ~ 26.8 nm. Furthermore, robust lysozyme coating layer self-organized on Fe3O4@SiO2 nanoparticles readily mediated heterogeneous nucleation growth MOF nanocrystals to form magnetic hierarchically UIO-66(Ce/Ti) core-shell nanocomposites (MHMUIO-66(Ce/Ti) CSNCs). The MHMUIO-66(Ce/Ti) CSNCs exhibited high BET surface area 471.6 m2·g− 1 large volume 0.39 cm3·g− 1, central 13.7 nm 7.8 24.5 nm, good chemical stability, superparamagnetic properties. Consequently, provided accessibility bimetallic Ce/Ti inside binding sites thus enhanced phosphopeptides enrichment performance low detection limit (0.5 fmol) selectivity (mass ratio β-casein/BSA, 1:1000). successful identification 24 enriched from an actual sample skim milk suggested that this method could be candidate for identifying phosphopeptide biomarkers in more complex biological samples.

Language: Английский

Citations

0