Porphyrin-Derived Carbon Dots for Red-Light Activated Photodynamic Therapy of Breast Cancer

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

In recent years, cancer has emerged as a major global health threat, ranking among the top causes of mortality. While treatments such surgery, immunotherapy, radiation therapy, and chemotherapy remain widely used, photodynamic therapy been gaining significant interest. Most photosensitizing agents employed in clinical settings are derived from tetrapyrrolic frameworks, including porphyrins, chlorins, phthalocyanines. Although these compounds have demonstrated therapeutic effectiveness, they suffer critical drawbacks, limited solubility water inadequate (photo)stability. To address issues, herein, formulation previously reported promising photosensitizer tetrakis(4-carboxyphenyl) porphyrin into carbon dots is reported. The were found with enhanced aqueous solubility, high (photo)stability, greater singlet oxygen quantum yield overcoming limitations molecular photosensitizer. being nontoxic dark, induced phototherapeutic effect breast cells multicellular tumor spheroids.

Language: Английский

Construction of Triphenylamine-Based Aggregation-Induced Emission Luminogens for Lysosomes Imaging and Its Application in the Photodynamic Therapy of Cancer Cells

Molecules, Journal Year: 2025, Volume and Issue: 30(11), P. 2272 - 2272

Published: May 22, 2025

Lysosomes are important acidic subcellular organelles whose dysfunction can lead to some related diseases. The development of new lysosome-imaging-guided AIEgens for the photodynamic therapy cancer cells is important. In this work, two novel organic compounds with AIE characteristics, namely, TPAB-CF3 and TPAB-diCF3, were designed synthesized by introducing weakly basic morpholinyl moiety lysosome-targeting ability into a triphenylamine-based luminogen. distorted spatial feature TPA D1-D2-π-A structure these prevented aggregation-caused quenching traditional fluorescent molecules efficiently promoted separation HOMO LUMO. outcomes features narrow single-triplet energy gap. Furthermore, TPAB-diCF3 showed bright yellow fluorescence emission peaks at 577 601 nm; large Stokes shifts 234 256 nm, respectively; excellent lysosome-targeted imaging HeLa (Pearson’s coefficient = 0.90). addition good 1O2-generation under light irradiation, achieved high-efficiency lysosome imaging-guided killing white-light irradiation.

Language: Английский

Photodynamic therapeutic activity of novel porphyrins against lung squamous cell carcinoma

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 28, 2025

Porphyrins, as drug-food homologous bioactive substances, hold significant potential in nanomedicine research and photodynamic therapy (PDT). In this study, we synthesized two novel porphyrin compounds, PTA PTBA, based on the compound TCPP. Using these prepared metal-porphyrin nanoparticles evaluated their properties. Results from multiple assays demonstrated that both PTBA exhibited significantly enhanced therapeutic activation under laser irradiation compared to This included improved reactive oxygen species (ROS) singlet release, well superior antitumor activity. When nanoparticles, all three compounds-PCN224 (TCPP with Zr⁴⁺), PMOF01 (PTA PMOF02 (PTBA Zr⁴⁺)-showed upregulated effects. These induced accumulation of ROS lung squamous cell carcinoma (LSCC) cells vitro vivo activity irradiation. Notably, much stronger effects PCN224 LSCC cells. Our findings highlight compounds nanoparticles. results not only expand our understanding porphyrins' capabilities but also provide new options for PDT applications.

Language: Английский