NIST Library Identification Probabilities Are the Highest with Cold EI Mass Spectra DOI Creative Commons
Aviv Amirav,

Benny Neumark,

Oneg Elkabets

et al.

Journal of the American Society for Mass Spectrometry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Cold EI improves all of the central GC-MS performance aspects, but even though it is known for providing enhanced molecular ions, important to realize that mass spectra also include standard fragment ions. Thus, are fully compatible with spectral libraries, such as NIST sample identification. As a result, (unlike any other soft ionization method) provide highly effective identifications often better than those obtained few reasons:1).Cold ions typically higher identification probabilities EI, scoring lower matching factors (false alternatives scores lowered much more).2).The visually observed further serve confirm or reject library identifications.3).Molecular isotope abundances our TAMI software automatic confirmation rejection and an elemental formula in case compound not library.4).The probability can be spectrum perfect match 999 by searching its own spectrum.5).The clear ion enables use option constraints search significantly increases probability. Our findings demonstrated hexadecane (n-C

Language: Английский

Cold EI—The Way to Improve GC‐MS and Increase Its Range of Applications DOI Creative Commons
Aviv Amirav,

Benny Neumark,

Oneg Elkabets

et al.

Mass Spectrometry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Gas chromatography-mass spectrometry (GC-MS) with Cold electron ionization (EI) is based on interfacing the GC and MS a supersonic molecular beam (SMB) along of vibrationally cold sample compounds in SMB contact-free fly-through ion source (hence name EI). EI improves all central performance aspects GC-MS, including: significantly extended range that are amenable for analysis, enhanced ions, highly improved identification, faster analysis (much faster), uniform response to analytes, greater selectivity higher signal noise ratios lower limits detection, particularly difficult analyze. GC-MS executes full standard applications most major improvements various metrics. Furthermore, it extends analysis. Accordingly, superior replacement source. In this review article, we describe its main features, discuss benefits, demonstrate several unique including cannabinoids synthetic organic whole blood medical diagnostics, isomer distribution fuels oils, explosives

Language: Английский

Citations

0
NIST Library Identification Probabilities Are the Highest with Cold EI Mass Spectra DOI Creative Commons
Aviv Amirav,

Benny Neumark,

Oneg Elkabets

et al.

Journal of the American Society for Mass Spectrometry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Cold EI improves all of the central GC-MS performance aspects, but even though it is known for providing enhanced molecular ions, important to realize that mass spectra also include standard fragment ions. Thus, are fully compatible with spectral libraries, such as NIST sample identification. As a result, (unlike any other soft ionization method) provide highly effective identifications often better than those obtained few reasons:1).Cold ions typically higher identification probabilities EI, scoring lower matching factors (false alternatives scores lowered much more).2).The visually observed further serve confirm or reject library identifications.3).Molecular isotope abundances our TAMI software automatic confirmation rejection and an elemental formula in case compound not library.4).The probability can be spectrum perfect match 999 by searching its own spectrum.5).The clear ion enables use option constraints search significantly increases probability. Our findings demonstrated hexadecane (n-C

Language: Английский

Citations

1