Low‐dose effect of developmental bisphenol A exposure on sperm count and behaviour in rats

Andrology, Journal Year: 2016, Volume and Issue: 4(4), P. 594 - 607

Published: April 18, 2016

Summary Bisphenol A is widely used in food contact materials and other products detected human urine blood. may affect reproductive neurological development; however, opinion of the European Food Safety Authority (EFSA) on bisphenol (EFSA J, 13, 2015 3978) concluded that none available studies were robust enough to provide a point departure for setting tolerable daily intake A. In present study, pregnant Wistar rats ( n = 17–21) gavaged from gestation day 7 pup 22 with doses 0, 25 μg, 250 5 mg or 50 mg/kg bw/day. offspring, growth, sexual maturation, weights histopathology organs, oestrus cyclicity sperm counts assessed. Neurobehavioural development was investigated using behavioural testing battery including tests motor activity, sweet preference, anxiety spatial learning. Decreased count found at lowest dose, μg/kg/day, but not higher doses. Reproductive organ weight histology affected no effects seen male offspring. female exposure μg/kg bw/day dose resulted increased body late life altered learning Morris water maze, indicating masculinization brain. sweetened females highest group, also possible sign masculinization. The endpoints significantly affected. conclusion, study experimental design, has shown developmental can cause adverse fertility (decreased count), neurodevelopment (masculinization females) lead life. These results suggest new EFSA temporary 4 sufficiently protective regard endocrine disrupting humans.

Language: Английский

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Low-dose effects of bisphenol A on early sexual development in male and female rats

Reproduction, Journal Year: 2013, Volume and Issue: 147(4), P. 477 - 487

Published: Dec. 3, 2013

Bisphenol A (BPA) is widely detected in human urine and blood. BPA has been reported to impair many endpoints for reproductive neurological development; however, it controversial whether effects the microgram per kilogram dose range. The aim of current study was examine influence on early sexual development male female rats at levels covering both regulatory no observed adverse effect (NOAELs) (5 50 mg/kg bw day) as well doses range (0.025 0.25 day). Time-mated Wistar (n=22) were gavaged during pregnancy lactation from gestation day 7 pup 22 with 0, 0.025, 0.25, 5 or BPA. From 0.250 above, anogenital distance (AGD) significantly decreased, whereas decreased AGD seen 0.025 above. Moreover, incidence nipple retention males appeared increase relatedly statistically significant day. No changes organ weights 16-day-old females signs maternal toxicity seen. birth sexes indicates prenatal provides new evidence low-dose NOAEL this clearly below BPA, which used basis establishment tolerable daily intake (TDI) by EFSA; thus a reconsideration TDI appears warranted.

Language: Английский

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Effect-based trigger values for in vitro bioassays: Reading across from existing water quality guideline values

Water Research, Journal Year: 2015, Volume and Issue: 81, P. 137 - 148

Published: May 27, 2015

Language: Английский

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Integrated procedure for determination of endocrine-disrupting activity in surface waters and sediments by use of the biological technique recombinant yeast assay and chemical analysis by LC?ESI-MS

Analytical and Bioanalytical Chemistry, Journal Year: 2004, Volume and Issue: 378(3), P. 697 - 708

Published: Feb. 1, 2004

Language: Английский

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A study on the migration of organic pollutants from recycled paperboard packaging materials to solid food matrices

Food Chemistry, Journal Year: 2006, Volume and Issue: 101(4), P. 1759 - 1768

Published: May 9, 2006

Language: Английский

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