COVID-19 and Artificial Intelligence: An Approach to Forecast the Severity of Diagnosis DOI Creative Commons
Ștefan Udriștoiu, Alice Elena Ghenea, Ștefan Udriștoiu

et al.

Life, Journal Year: 2021, Volume and Issue: 11(11), P. 1281 - 1281

Published: Nov. 22, 2021

(1) Background: The new SARS-COV-2 pandemic overwhelmed intensive care units, clinicians, and radiologists, so the development of methods to forecast diagnosis’ severity became a necessity helpful tool. (2) Methods: In this paper, we proposed an artificial intelligence-based multimodal approach future patients with laboratory-confirmed cases SARS-CoV-2 infection. At hospital admission, collected 46 clinical biological variables chest X-ray scans from 475 COVID-19 positively tested patients. An ensemble machine learning algorithms (AI-Score) was developed predict score as mild, moderate, severe for COVID-19-infected Additionally, deep module (CXR-Score) automatically classify images integrate them into AI-Score. (3) Results: AI-Score predicted on testing/control dataset (95 patients) average accuracy 98.59%, specificity 98.97%, sensitivity 97.93%. CXR-Score graded 99.08% images). (4) Conclusions: Our study demonstrated that based integration data accurately positive-tested

Language: Английский

[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis DOI Creative Commons
Javad Sharifi‐Rad, Cristina Quispe, Jesús Herrera‐Bravo

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Medicinal plants are being used worldwide for centuries their beneficial properties. Some of the most popular medicinal belong to

Language: Английский

Citations

52
Suicidality and COVID‑19: Suicidal ideation, suicidal behaviors and completed suicides amidst the COVID‑19 pandemic (Review) DOI Open Access
Vasiliki Efstathiou, Maria‐Ioanna Stefanou, Nikolaos Siafakas

et al.

Experimental and Therapeutic Medicine, Journal Year: 2021, Volume and Issue: 23(1)

Published: Dec. 2, 2021

Since the outbreak of coronavirus 2019 (COVID‑19) pandemic, there has been widespread concern that social isolation, financial stress, depression, limited or variable access to health care services and other pandemic‑related stressors may contribute an increase in suicidal behaviors. In patients who have recovered from COVID‑19, increased risk developing behaviors be noted, while post‑COVID syndrome comprises another potential factor contributing Despite initial alarming predictions for suicide rates due COVID‑19 majority published studies date suggest experienced difficulties distress do not inevitably translate into number suicide‑related deaths, at least short‑term. Nevertheless, long‑term mental effects pandemic yet unfolded are likely remain a long period time. Suicide prevention measures aiming promoting well‑being mitigating on health, particularly among vulnerable groups, should thus priority healthcare professionals policymakers amidst evolving pandemic.

Language: Английский

Citations

49
Reversal of brain aging by targeting telomerase: A nutraceutical approach DOI Creative Commons
Dimitris Tsoukalas, Ana Maria Bugă, Anca Oana Docea

et al.

International Journal of Molecular Medicine, Journal Year: 2021, Volume and Issue: 48(5)

Published: Sept. 10, 2021

Telomeres, the protective caps of chromosomes, shorten with age, as telomerase, enzyme responsible for compensation telomere erosion, is inactive in majority cells. Telomere shortening and subsequent cell senescence lead to tissue aging age‑related diseases. Neurodegenerative disorders, characterized by progressive loss neurons among other hallmarks aged tissue, poor cognitive function, have been associated a short length. Thus, telomerase activity has emerged therapeutic target, novel agents being under investigation. The present study aimed examine effects natural activator, 'Reverse™', containing

Language: Английский

Citations

36
RETRACTED: Why are we vaccinating children against COVID-19? DOI Creative Commons
Ronald N. Kostoff, Daniela Călina, Darja Kanduc

et al.

Toxicology Reports, Journal Year: 2021, Volume and Issue: 8, P. 1665 - 1684

Published: Jan. 1, 2021

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). The retracted at the request of Founding Editor, Prof. Lawrence H. Lash, basis that there is clear evidence findings are unreliable: https://publicationethics.org/files/retraction-guidelines-cope.pdf. focus paper a critically important public health issue. As such, it essential presentation be accurate and balanced. Additional external review this following publication concluded demonstrates inappropriate bias in multiple ways. use key terminology, specifically terms "inoculation" "vaccination" diverges from common incorrect, indicating bias. Publicly available data United States Center for Disease Control (U.S. CDC) were by reviewers to misinterpreted make erroneous conclusion vast majority reported deaths due COVID-19 actually other comorbidities. Such an egregious misinterpretation misrepresentation unacceptable.

Language: Английский

Citations

35
Glycyrrhizin as a promising kryptonite against SARS-CoV-2: Clinical, experimental, and theoretical evidences DOI Open Access
Suvankar Banerjee, Sandip Kumar Baidya, Nilanjan Adhikari

et al.

Journal of Molecular Structure, Journal Year: 2022, Volume and Issue: 1275, P. 134642 - 134642

Published: Nov. 25, 2022

Language: Английский

Citations

25
Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature-Based Review DOI Creative Commons
Rajib Hossain, Cristina Quispe, Jesús Herrera‐Bravo

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Lasia spinosa (L.) is used ethnobotanically for the treatment of various diseases, including rheumatoid arthritis, inflammation lungs, bleeding cough, hemorrhoids, intestinal stomach pain, and uterine cancer. This review aimed at summarizing phytochemistry pharmacological data with their molecular mechanisms action. A search was performed in databases such as PubMed, Science Direct, Google Scholar using keywords: “ ,” then combined “ethnopharmacological use,” “phytochemistry,” “pharmacological activity.” updated included studies vitro, ex vivo, vivo experiments compounds known concentration highlighted mechanisms. The research results showed that L. contains many important nutritional phytochemical components alkanes, aldehydes, alkaloids, carotenoids, flavonoids, fatty acids, ketones, lignans, phenolics, terpenoids, steroids, volatile oil excellent bioactivity. importance this lies fact scientific evidence supports plant has antioxidant, anti‐inflammatory, antimicrobial, cytotoxic, antidiarrheal, antihelminthic, antidiabetic, antihyperlipidemic, antinociceptive effects, while protecting gastrointestinal system reproductive. Regarding future toxicological safety data, more needed, on human subjects. In light these can be considered a medicinal effective bioactives adjuvant diseases humans.

Language: Английский

Citations

32
Challenges and Scientific Prospects of the Newest Generation of mRNA-Based Vaccines against SARS-CoV-2 DOI Creative Commons
Daniela Călina, Antonio F. Hernández, Thomas Härtung

et al.

Life, Journal Year: 2021, Volume and Issue: 11(9), P. 907 - 907

Published: Aug. 31, 2021

In the context of current COVID-19 pandemic, traditional, complex and lengthy methods vaccine development production would not have been able to ensure proper management this global public health crisis. Hence, a number technologies developed for obtaining quickly ensuring large scale production, such as mRNA-based platforms. The use mRNA is new concept in but has leveraged on previous knowledge technology. great human resources capital investements development, along with experience gained from studies infectious diseases, allowed vaccines be developed, conditionally approved commercialy available less than one year, thanks decades basic research. This review critically presents discusses vaccine-induced immunity, it summarizes most common anaphylactic autoimmune adverse effects that identified until now after massive vaccination campaigns.

Language: Английский

Citations

30
Exploring Structural Mechanism of COVID-19 Treatment with Glutathione as a Potential Peptide Inhibitor to the Main Protease: Molecular Dynamics Simulation and MM/PBSA Free Energy Calculations Study DOI Open Access
Abderahmane Linani, Khedidja Benarous, Leila Bou-Salah

et al.

International Journal of Peptide Research and Therapeutics, Journal Year: 2022, Volume and Issue: 28(2)

Published: Jan. 21, 2022

Language: Английский

Citations

19
Revisiting the nutraceutical profile, chemical composition, and health benefits of jaggery: Updates from recent decade DOI Creative Commons
Javad Sharifi‐Rad, Sakshi Painuli, Bilge Şener

et al.

eFood, Journal Year: 2023, Volume and Issue: 4(2)

Published: Feb. 27, 2023

Abstract Foods as medicine have been utilized from ancient civilizations and shared generation to dietary health practices. It provides therapeutic assistance along with nutrition benefits. Presently, food products, diet, individual are receiving a lot of attention in high demand. In this context, jaggery is an important part diet the rural areas many regions/countries. made up sugarcane juice recognized natural source nutraceuticals due presence different types essential amino acids, minerals, vitamins, antioxidant potential other biological applications. updated review article, we discussed newest research information on traditional uses, nutraceutical profiling, chemical composition, applications jaggery. The published data were collected scientific search engines including PubMed, Springer Link, Web Science, Google Scholar, Science Direct, Wiley online library. Given these findings, can conclude that strong its be enhanced value addition interventions. Detailed investigations preclinical (in silico, vitro , vivo ) studies actual mechanism action depth required. Additionally, clinical trials also should conducted validate studies.

Language: Английский

Citations

13
Potential treatments of COVID-19: Drug repurposing and therapeutic interventions DOI Creative Commons
Pawan Kumar Raghav,

Zoya Mann,

Simran Kaur Ahluwalia

et al.

Journal of Pharmacological Sciences, Journal Year: 2023, Volume and Issue: 152(1), P. 1 - 21

Published: Feb. 15, 2023

The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome 2 (SARS-CoV-2). infection when Spike-protein (S-protein) present on the surface of SARS-CoV-2 interacts with human cell receptor, Angiotensin-converting enzyme (ACE2). This binding facilitates genome entry into cells, which in turn causes infection. Since beginning pandemic, many different therapies have been developed to combat COVID-19, including treatment and prevention. review focused currently adapted certain other potential for COVID-19 treatment, include drug repurposing, vaccines drug-free therapies. efficacy various options constantly being tested through clinical trials vivo studies before they are made medically available public.

Language: Английский

Citations

12