Reactive Oxygen Species in Metabolic and Inflammatory Signaling

Circulation Research, Journal Year: 2018, Volume and Issue: 122(6), P. 877 - 902

Published: March 15, 2018

Reactive oxygen species (ROS) are well known for their role in mediating both physiological and pathophysiological signal transduction. Enzymes subcellular compartments that typically produce ROS associated with metabolic regulation, diseases dysfunction may be influenced by changes redox balance. In this review, we summarize the current literature surrounding inflammatory focusing on transduction its relationship to disease progression. particular, examine production such as cytoplasm, mitochondria, peroxisome, endoplasmic reticulum discuss how influence processes proteasome function, autophagy, general signaling. We also highlight of regulation metabolic/inflammatory including atherosclerosis, diabetes mellitus, stroke. order develop therapies target oxidative signaling, it is vital understand balance signaling plays physiology pathophysiology, manipulation identity cellular tissue homeostasis. An increased understanding specific sources an appreciation metabolism help guide us effort treat cardiovascular diseases.

Language: Английский

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Nrf2 signaling pathway: Pivotal roles in inflammation

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2016, Volume and Issue: 1863(2), P. 585 - 597

Published: Nov. 4, 2016

Language: Английский

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Inflammatory mechanisms in patients with chronic obstructive pulmonary disease

Journal of Allergy and Clinical Immunology, Journal Year: 2016, Volume and Issue: 138(1), P. 16 - 27

Published: May 28, 2016

Language: Английский

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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Nature Immunology, Journal Year: 2020, Volume and Issue: 21(7), P. 736 - 745

Published: May 4, 2020

Language: Английский

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Triggering and resolution of inflammation in NASH

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2018, Volume and Issue: 15(6), P. 349 - 364

Published: May 8, 2018

Language: Английский

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Mitochondria as a therapeutic target for common pathologies

Nature Reviews Drug Discovery, Journal Year: 2018, Volume and Issue: 17(12), P. 865 - 886

Published: Nov. 5, 2018

Language: Английский

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Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: June 25, 2018

Oridonin (Ori) is the major active ingredient of traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but target Ori remains unknown. NLRP3 a central component inflammasome been involved in wide variety chronic inflammation-driven human diseases. Here, we show that specific covalent inhibitor for inflammasome. forms bond with cysteine 279 NACHT domain to block interaction between NEK7, thereby inhibiting assembly activation. Importantly, both preventive or therapeutic effects on mouse models peritonitis, gouty arthritis type 2 diabetes, via inhibition Our results thus identify as direct mediating Ori's activity. could serve lead developing new therapeutics against NLRP3-driven

Language: Английский

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Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

The Journal of Experimental Medicine, Journal Year: 2017, Volume and Issue: 214(11), P. 3219 - 3238

Published: Oct. 11, 2017

The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety human diseases. A few compounds have developed to inhibit activation, but directly and specifically targeting are still not available, so it is unclear whether itself can be targeted prevent or treat Here we show that compound CY-09 blocks activation. binds ATP-binding motif NACHT domain inhibits ATPase activity, resulting suppression assembly Importantly, treatment with shows remarkable therapeutic effects on mouse models cryopyrin-associated autoinflammatory syndrome (CAPS) type 2 diabetes. Furthermore, active ex vivo for monocytes from healthy individuals synovial fluid cells patients gout. Thus, our results provide selective direct small-molecule inhibitor indicate combat NLRP3-driven

Language: Английский

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Reactive oxygen species (ROS) in macrophage activation and function in diabetes

Immunobiology, Journal Year: 2018, Volume and Issue: 224(2), P. 242 - 253

Published: Dec. 1, 2018

Language: Английский

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Cellular and molecular mechanisms of asthma and COPD

Clinical Science, Journal Year: 2017, Volume and Issue: 131(13), P. 1541 - 1558

Published: June 28, 2017

Asthma and chronic obstructive pulmonary disease (COPD) both cause airway obstruction are associated with inflammation of the airways. However, nature sites differ between these diseases, resulting in different pathology, clinical manifestations response to therapy. In this review, inflammatory cellular mechanisms asthma COPD compared differences cells profile mediators highlighted. These account for their Although usually distinct, there some patients who show an overlap features, which may be explained by coincidence two common diseases or distinct phenotypes each disease. It is important better understand underlying molecular order develop new treatments areas unmet need, such as severe asthma, curative therapy effective anti-inflammatory COPD.

Language: Английский

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