Prevotella copri in individuals at risk for rheumatoid arthritis

Annals of the Rheumatic Diseases, Journal Year: 2019, Volume and Issue: 78(5), P. 590 - 593

Published: Feb. 13, 2019

Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome composition and prevalence Prevotella spp. in group individuals at increased risk for RA, but prior to development disease.In an ongoing cohort study first-degree relatives (FDRs) patients we identified 'FDR controls', asymptomatic without autoantibodies, pre-clinical RA stages, who had either developed anticitrullinated peptide antibodies or rheumatoid factor positivity and/or symptoms signs possible RA. Stool sampling culture-independent microbiota analyses were performed followed by descriptive statistics statistical community structures.A total 133 participants included, which 50 categorised as controls' 83 'pre-clinical stages'. The stages' was significantly altered compared FDR controls. We found significant enrichment bacterial family Prevotellaceae, particularly spp., RA' (p=0.04).Prevotella stages before onset suggests role intestinal dysbiosis

Language: Английский

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Mass spectrometry-based metabolomics in microbiome investigations

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 20(3), P. 143 - 160

Published: Sept. 22, 2021

Language: Английский

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Adaptive immunity: an emerging player in the progression of NAFLD

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2019, Volume and Issue: 17(2), P. 81 - 92

Published: Oct. 11, 2019

Language: Английский

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Primary biliary cholangitis: pathogenesis and therapeutic opportunities

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2019, Volume and Issue: 17(2), P. 93 - 110

Published: Dec. 9, 2019

Language: Английский

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Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Signal Transduction and Targeted Therapy, Journal Year: 2019, Volume and Issue: 4(1)

Published: Oct. 11, 2019

Abstract The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects host pathophysiology. Remarkable progress large-scale sequencing mass spectrometry has increased our understanding influence and/or its metabolites onset progression extraintestinal cancers efficacy cancer immunotherapy. Given plasticity microbial composition function, microbial-based therapeutic interventions, including dietary modulation, prebiotics, probiotics, as well fecal transplantation, potentially permit development novel strategies for therapy improve clinical outcomes. Herein, we summarize latest evidence involvement immunity metabolism, effects immune response, modulate microbiome, discuss ongoing studies future areas research that deserve focused efforts.

Language: Английский

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Nanotechnology intervention of the microbiome for cancer therapy

Nature Nanotechnology, Journal Year: 2019, Volume and Issue: 14(12), P. 1093 - 1103

Published: Dec. 1, 2019

Language: Английский

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The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Oct. 9, 2019

Microfold (M) cells are located in the epithelium covering mucosa-associated lymphoid tissues, such as Peyer's patches (PPs) of small intestine. M actively transport luminal antigens to underlying follicles initiate an immune response. The molecular machinery M-cell differentiation and function has been vigorously investigated over last decade. Studies have shed light on role mucosal system revealed that antigen uptake by contributes not only but also systemic responses. However, studies usually focus infectious diseases; contribution autoimmune diseases remained largely unexplored. Accumulating evidence suggests dysbiosis intestinal microbiota is implicated multiple diseases, including diseases. This implies microorganisms PPs may play a pathogenesis In this review, we relationship between commensal bacteria We provide outline current understanding biology subsequently discuss potential induction autoimmunity, beyond

Language: Английский

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IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: June 26, 2020

The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate mucosal adaptive and innate immune cells defense against pathogens. IL-10 IL-22 most well studied members family play essential roles maintaining homeostasis. serves as an important regulator preventing pro-inflammatory responses while plays a protective role tissue damage contributes to pathology certain settings. In this review, we focus on these two cytokines development diseases, including inflammatory bowel diseases (IBD) colitis-associated cancer (CAC). We summarize recent studies try gain better understanding how they regulate maintain equilibrium under conditions.

Language: Английский

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Leveraging diet to engineer the gut microbiome

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2021, Volume and Issue: 18(12), P. 885 - 902

Published: Sept. 27, 2021

Language: Английский

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The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping

Cell Host & Microbe, Journal Year: 2021, Volume and Issue: 30(1), P. 124 - 138.e8

Published: Dec. 30, 2021

Human health and disease have increasingly been shown to be impacted by the gut microbiota, mouse models are essential for investigating these effects. However, compositions of human microbiotas distinct, limiting translation microbiota research between hosts. To address this, we constructed Mouse Gastrointestinal Bacteria Catalogue (MGBC), a repository 26,640 high-quality microbiota-derived bacterial genomes. This catalog enables species-level analyses mapping functions interest identifying functionally equivalent taxa humans mice. We complemented this with publicly deposited collection 223 isolates, including 62 previously uncultured species, facilitate experimental investigation individual commensal bacteria in vitro vivo. Together, resources provide ability identify test members host-specific mice support informed use research.

Language: Английский

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