Efficacy of Myopia Prevention in At-Risk Children: A Systematic Review and Network Meta-Analysis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1665 - 1665

Published: Feb. 28, 2025

Objectives: To evaluate the efficacy of myopia prevention methods in children without pre-existing myopia. Methods: A network meta-analysis was conducted following PRISMA-NMA guidelines. Comprehensive searches were performed PubMed, Embase, and Cochrane CENTRAL databases. The analysis focused on randomized controlled trials evaluating strategies prior Primary outcomes included annual changes refraction axial length, while secondary encompassed incidence adverse events. Effect sizes reported as risk ratios (RR) or mean differences (MD) with 95% confidence intervals (CIs). Data synthesis utilized a random-effects model under frequentist framework, intervention ranked by P-scores. Study quality assessed using risk-of-bias tool, robustness ensured via sensitivity consistency analyses. Results: Low-level red light therapy low-dose atropine most effective interventions for reducing refractive progression (MD: 0.48 D, CI: 0.38–0.59 D; MD: 0.33 0.23–0.43 D) elongation −0.23 mm, −0.27 to −0.19 mm; −0.12 −0.16 −0.08 mm). In addition, both significantly lowered (RR: 0.59, 0.45–0.79; RR: 0.55, 0.41–0.75). Outdoor activities awareness programs demonstrated moderate efficacy. Adverse events, including photophobia dry eyes, minor self-limiting, no serious complications reported. Conclusions: are effective, generally safe preventing at-risk myopia, non-invasive approach, outdoor activities, provides benefits.

Language: Английский

---

A Survey on the Off-Label Use of Atropine in the Treatment of Myopia in Italy

Ophthalmic Epidemiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 4

Published: March 4, 2025

Language: Английский

---

Myopia control efficacy of spectacle lenses with highly aspherical lenslets: results of a 5-year follow-up study

Eye and Vision, Journal Year: 2025, Volume and Issue: 12(1)

Published: March 5, 2025

To evaluate myopia control efficacy in myopic children wearing spectacle lenses with highly aspherical lenslets (HAL) for 5 years. This is a randomized, double-masked extended trial. Myopic aged 8 to 13 years who were originally allocated the HAL group 2-year clinical The underwent 5-year assessment progression using cycloplegic spherical equivalent refraction (SER) and axial length (AL). An extrapolated single-vision (ESVL) was used as group. elongation of ESVL calculated based on data from same trial, following 3 estimated by assuming an annual reduction SER 9.7% AL 15%. A generalized linear model approach treatment efficacy. validity evaluated comparing first year 3-year estimates (SVL2) 1-year study Forty-three participants original completed visit (74%). Five-year [mean ± standard error (SE)] - 1.27 0.14 D. Compared (- 3.03 0.18 D), 1.75 0.24 D less (P < 0.001). mean over 0.67 0.06 mm compared 1.40 0.001), slower 0.72 0.10 No significant differences found 0.58 0.04 vs. 0.56 0.05 D) or (0.28 0.02 0.28 mm) between SVL2 (PSER = 0.83; PAL 0.93) 3. In this study, spectacles reduced rate elongation, preventing elongation. Long-term use also decreased incidence high myopia. Extrapolated groups are valid evaluating long-term studies. Trial registration registered at Chinese Clinical Registry (ChiCTR2100047262), https://www.chictr.org.cn/showproj.html?proj=127182 .

Language: Английский

---

Efficacy of outdoor interventions for myopia in children and adolescents: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 13, 2024

Objectives The objective of this systematic review and meta-analysis was to evaluate the overall efficacy outdoor interventions for myopia in children adolescents, provide evidence prevention control myopia. Methods Randomized controlled trials adolescents were identified using electronic databases manual searches. Revised Cochrane risk-of-bias tool randomized (RoB 2) used assess risk bias trials. A mean difference (MD) a ratio (RR) with 95% confidence interval (CI) combine effect sizes. sensitivity analysis performed each outcome stepwise elimination method whether pooled results significantly affected by individual studies. Results included seven involving total 9,437 subjects. showed marked statistically significant improvements spherical equivalent refraction (MD = 0.19; CI 0.14 0.25; p &lt; 0.01), axial length −0.09; −0.13 −0.05; incidence (RR 0.84; 0.78 0.91; 0.01) following interventions. Conclusion Outdoor effectively contributed positively impacting refraction, length, incidence. characterized low high therapeutic benefits could serve as alternative or adjuvant approaches medication treatment Considering advantages terms safety efficacy, may be considered preferred intervention while susceptibility diseases associated sunlight, particularly UV exposure, must taken into account. Systematic registration https://www.crd.york.ac.uk/prospero/ , Identifier CRD42024538695.

Language: Английский

---

Low-concentration Atropine for Controlling Myopia Onset and Progression in East Asia

Asia-Pacific Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: unknown, P. 100122 - 100122

Published: Dec. 1, 2024

Over the past few years, there has been a rapid accumulation of data on use low-concentration atropine for myopia control, especially in East Asian children, with its effectiveness varying different studies. This review aims to evaluate current evidence surrounding efficacy and safety management onset progression Asia.

Language: Английский

---