Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(8), P. 458 - 468
Published: July 20, 2015
Language: Английский
Neuron, Journal Year: 2016, Volume and Issue: 91(2), P. 260 - 292
Published: July 1, 2016
Language: Английский
Citations
1876
Nature, Journal Year: 2014, Volume and Issue: 505(7483), P. 318 - 326
Published: Jan. 1, 2014
Language: Английский
Citations
1086
Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 294 - 313
Published: Oct. 1, 2018
Language: Английский
Citations
598
Pharmacological Reviews, Journal Year: 2021, Volume and Issue: 73(4), P. 1469 - 1658
Published: Oct. 1, 2021
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs). These ligand-gated ion channels critical to brain function and centrally implicated numerous psychiatric neurologic disorders. There different classes iGluRs with a variety receptor subtypes each class that play distinct roles neuronal functions. The diversity iGluR subtypes, their unique functional properties roles, has motivated large number studies. Our understanding advanced considerably since first subunit gene was cloned 1989, research focus expanded encompass facets biology have been recently discovered exploit experimental paradigms made possible technological advances. Here, we review insights from more than 3 decades studies an emphasis on progress occurred past decade. We cover structure, function, pharmacology, neurophysiology, therapeutic implications for all assembled subunits encoded 18 genes. SIGNIFICANCE STATEMENT: Glutamate important virtually aspects either involved mediating some clinical features neurological disease or represent target treatment. Therefore, pharmacology this will advance our many at molecular, cellular, system levels provide new opportunities treat patients.
Language: Английский
Citations
461
Neuroscience & Biobehavioral Reviews, Journal Year: 2012, Volume and Issue: 36(9), P. 2044 - 2055
Published: July 25, 2012
Language: Английский
Citations
412
Neuron, Journal Year: 2013, Volume and Issue: 77(3), P. 388 - 405
Published: Feb. 1, 2013
Language: Английский
Citations
398
Nature, Journal Year: 2016, Volume and Issue: 535(7612), P. 367 - 375
Published: July 1, 2016
Language: Английский
Citations
382
Trends in Genetics, Journal Year: 2013, Volume and Issue: 29(8), P. 461 - 468
Published: April 4, 2013
Language: Английский
Citations
305
Nature, Journal Year: 2020, Volume and Issue: 598(7879), P. 144 - 150
Published: Nov. 12, 2020
Abstract Cortical neurons exhibit extreme diversity in gene expression as well morphological and electrophysiological properties 1,2 . Most existing neural taxonomies are based on either transcriptomic 3,4 or morpho-electric 5,6 criteria, it has been technically challenging to study both aspects of neuronal the same set cells 7 Here we used Patch-seq 8 combine patch-clamp recording, biocytin staining, single-cell RNA sequencing more than 1,300 adult mouse primary motor cortex, providing a annotation almost all transcriptomically defined cell types. We found that, although broad families types (those expressing Vip , Pvalb Sst so on) had distinct essentially non-overlapping phenotypes, individual within family were not separated space. Instead, there was continuum variability morphology electrophysiology, with neighbouring showing similar features, often without clear boundaries between them. Our results suggest that neocortex do always form discrete entities. hierarchy consists branches at level families, but can continuous correlated morpho-electrical landscapes families.
Language: Английский
Citations
301
Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(5), P. 299 - 309
Published: April 6, 2017
Language: Английский
Citations
288