The BCM theory of synapse modification at 30: interaction of theory with experiment

Nature reviews. Neuroscience, Journal Year: 2012, Volume and Issue: 13(11), P. 798 - 810

Published: Oct. 19, 2012

Language: Английский

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The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)

Annual Review of Neuroscience, Journal Year: 2012, Volume and Issue: 35(1), P. 417 - 443

Published: May 20, 2012

Fragile X is the most common known inherited cause of intellectual disability and autism, it typically results from transcriptional silencing FMR1 loss encoded protein, FMRP (fragile mental retardation protein). an mRNA-binding protein that functions at many synapses to inhibit local translation stimulated by metabotropic glutamate receptors (mGluRs) 1 5. Recent studies on biology signaling pathways downstream mGluR1/5 have yielded deeper insight into how synaptic synthesis plasticity are regulated experience. This new knowledge has also suggested ways altered function can be corrected in fragile X, human clinical trials based this information under way.

Language: Английский

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Molecular neurobiology of mTOR

Neuroscience, Journal Year: 2016, Volume and Issue: 341, P. 112 - 153

Published: Nov. 23, 2016

Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that controls several important aspects mammalian cell function. mTOR activity modulated by various intra- and extracellular factors; in turn, changes rates translation, transcription, protein degradation, signaling, metabolism, cytoskeleton dynamics. has been repeatedly shown to participate neuronal development the proper functioning mature neurons. Changes are often observed nervous system diseases, including genetic diseases (e.g., tuberous sclerosis complex, Pten-related syndromes, neurofibromatosis, Fragile X syndrome), epilepsy, brain tumors, neurodegenerative disorders (Alzheimer's disease, Parkinson's Huntington's disease). Neuroscientists only recently began deciphering molecular processes downstream function system. As result, we gaining knowledge about ways which aberrant lead diseases. In this review, provide comprehensive view system, with special focus on functions control autophagy) likely underlie contribution

Language: Английский

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Exaggerated translation causes synaptic and behavioural aberrations associated with autism

Nature, Journal Year: 2012, Volume and Issue: 493(7432), P. 411 - 415

Published: Dec. 21, 2012

Language: Английский

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mTOR complexes in neurodevelopmental and neuropsychiatric disorders

Nature Neuroscience, Journal Year: 2013, Volume and Issue: 16(11), P. 1537 - 1543

Published: Oct. 28, 2013

Language: Английский

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