Current Opinion in Gastroenterology,
Journal Year:
2014,
Volume and Issue:
31(1), P. 69 - 75
Published: Nov. 12, 2014
Recent
technological
advancements
and
expanded
efforts
have
led
to
a
tremendous
growth
in
the
collective
knowledge
of
human
microbiome.
This
review
will
highlight
some
important
recent
findings
this
area
research.Studies
described
structure
functional
capacity
bacterial
microbiome
healthy
state
variety
disease
states.
Downstream
analyses
interactions
between
host
its
are
starting
provide
mechanistic
insights
into
these
interactions.
These
data
anticipated
lead
new
opportunities
for
diagnosis,
prognosis,
treatment
diseases.There
is
fast
growing
collection
describing
conditions
available
research
community
consideration
further
exploration.
Ongoing
characterize
functions
mechanisms
underlying
host-microbe
better
understanding
role
health
disease.
Frontiers in Endocrinology,
Journal Year:
2020,
Volume and Issue:
11
Published: Jan. 31, 2020
A
substantial
body
of
evidence
supports
that
the
gut
microbiota
plays
a
pivotal
role
in
regulation
metabolic,
endocrine
and
immune
functions.
In
recent
years,
there
has
been
growing
recognition
involvement
modulation
multiple
neurochemical
pathways
through
highly
interconnected
gut-brain
axis.
Although
amazing
scientific
breakthroughs
over
last
few
years
have
expanded
our
knowledge
on
communication
between
microbes
their
hosts,
underpinnings
microbiota-gut-brain
crosstalk
remain
to
be
determined.
Short-chain
fatty
acids
(SCFAs),
main
metabolites
produced
colon
by
bacterial
fermentation
dietary
fibers
resistant
starch,
are
speculated
play
key
neuro-immunoendocrine
regulation.
However,
underlying
mechanisms
which
SCFAs
might
influence
brain
physiology
behavior
not
fully
elucidated.
this
review,
we
will
outline
current
about
interactions.
We
also
highlight
how
development
future
treatments
for
central
nervous
system
(CNS)
disorders
can
take
advantage
intimate
mutual
interactions
with
exploring
function.
Science,
Journal Year:
2018,
Volume and Issue:
359(6380), P. 1151 - 1156
Published: March 8, 2018
The
gut
microbiota
benefits
humans
via
short-chain
fatty
acid
(SCFA)
production
from
carbohydrate
fermentation,
and
deficiency
in
SCFA
is
associated
with
type
2
diabetes
mellitus
(T2DM).
We
conducted
a
randomized
clinical
study
of
specifically
designed
isoenergetic
diets,
together
fecal
shotgun
metagenomics,
to
show
that
select
group
SCFA-producing
strains
was
promoted
by
dietary
fibers
most
other
potential
producers
were
either
diminished
or
unchanged
patients
T2DM.
When
the
fiber-promoted
present
greater
diversity
abundance,
participants
had
better
improvement
hemoglobin
A1c
levels,
partly
increased
glucagon-like
peptide-1
production.
Promotion
these
positive
responders
metabolically
detrimental
compounds
such
as
indole
hydrogen
sulfide.
Targeted
restoration
may
novel
ecological
approach
for
managing
PeerJ,
Journal Year:
2015,
Volume and Issue:
3, P. e1165 - e1165
Published: Aug. 27, 2015
Grouping
large
genomic
fragments
assembled
from
shotgun
metagenomic
sequences
to
deconvolute
complex
microbial
communities,
or
metagenome
binning,
enables
the
study
of
individual
organisms
and
their
interactions.
Because
nature
these
existing
binning
methods
often
miss
a
number
species.
In
addition,
most
tools
are
not
scalable
datasets.
Here
we
introduce
automated
software
called
MetaBAT
that
integrates
empirical
probabilistic
distances
genome
abundance
tetranucleotide
frequency
for
accurate
binning.
outperforms
alternative
in
accuracy
computational
efficiency
on
both
synthetic
real
It
automatically
forms
hundreds
high
quality
bins
very
assembly
consisting
millions
contigs
matter
hours
single
node.
is
open
source
available
at
https://bitbucket.org/berkeleylab/metabat.
