International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(20), P. 7794 - 7794
Published: Oct. 21, 2020
Emerging
autologous
cellular
therapies
that
utilize
platelet-rich
plasma
(PRP)
applications
have
the
potential
to
play
adjunctive
roles
in
a
variety
of
regenerative
medicine
treatment
plans.
There
is
global
unmet
need
for
tissue
repair
strategies
treat
musculoskeletal
(MSK)
and
spinal
disorders,
osteoarthritis
(OA),
patients
with
chronic
complex
recalcitrant
wounds.
PRP
therapy
based
on
fact
platelet
growth
factors
(PGFs)
support
three
phases
wound
healing
cascade
(inflammation,
proliferation,
remodeling).
Many
different
formulations
been
evaluated,
originating
from
human,
vitro,
animal
studies.
However,
recommendations
vitro
research
often
lead
clinical
outcomes
because
it
difficult
translate
non-clinical
study
methodology
human
protocols.
In
recent
years,
progress
has
made
understanding
technology
concepts
bioformulation,
new
directives
indications
suggested.
this
review,
we
will
discuss
developments
regarding
preparation
composition
dosing,
leukocyte
activities
concerning
innate
adaptive
immunomodulation,
serotonin
(5-HT)
effects,
pain
killing.
Furthermore,
mechanisms
related
inflammation
angiogenesis
processes.
Lastly,
review
effect
certain
drugs
activity,
combination
rehabilitation
Cell Death and Differentiation,
Journal Year:
2018,
Volume and Issue:
25(3), P. 486 - 541
Published: Jan. 23, 2018
Over
the
past
decade,
Nomenclature
Committee
on
Cell
Death
(NCCD)
has
formulated
guidelines
for
definition
and
interpretation
of
cell
death
from
morphological,
biochemical,
functional
perspectives.
Since
field
continues
to
expand
novel
mechanisms
that
orchestrate
multiple
pathways
are
unveiled,
we
propose
an
updated
classification
subroutines
focusing
mechanistic
essential
(as
opposed
correlative
dispensable)
aspects
process.
As
provide
molecularly
oriented
definitions
terms
including
intrinsic
apoptosis,
extrinsic
mitochondrial
permeability
transition
(MPT)-driven
necrosis,
necroptosis,
ferroptosis,
pyroptosis,
parthanatos,
entotic
death,
NETotic
lysosome-dependent
autophagy-dependent
immunogenic
cellular
senescence,
mitotic
catastrophe,
discuss
utility
neologisms
refer
highly
specialized
instances
these
processes.
The
mission
NCCD
is
a
widely
accepted
nomenclature
in
support
continued
development
field.
