GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

Neuron, Journal Year: 2016, Volume and Issue: 91(2), P. 260 - 292

Published: July 1, 2016

Language: Английский

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Synaptic Plasticity Forms and Functions

Annual Review of Neuroscience, Journal Year: 2020, Volume and Issue: 43(1), P. 95 - 117

Published: Feb. 20, 2020

Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long been considered an important component of learning and memory. Computational engineering work corroborate power through directed adjustment weights. Here we review fundamental elements four broadly categorized forms synaptic plasticity discuss their functional capabilities limitations. Although standard, correlation-based, Hebbian primary focus neuroscientists for decades, it is inherently limited. Three-factor rules supplement with neuromodulation eligibility traces, while true supervised types go even further by adding objectives instructive signals. Finally, a recently discovered hippocampal form combines above elements, leaving behind requirement. We suggest that effort to determine neural basis adaptive behavior could benefit from renewed experimental theoretical investigation more powerful plasticity.

Language: Английский

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Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 18(8), P. 1133 - 1142

Published: July 13, 2015

Language: Английский

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Dendritic integration: 60 years of progress

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 18(12), P. 1713 - 1721

Published: Nov. 25, 2015

Language: Английский

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Thalamic functions in distributed cognitive control

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(12), P. 1669 - 1679

Published: Nov. 9, 2017

Language: Английский

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Plasticity of Cortical Excitatory-Inhibitory Balance

Annual Review of Neuroscience, Journal Year: 2015, Volume and Issue: 38(1), P. 195 - 219

Published: April 21, 2015

Synapses are highly plastic and modified by changes in patterns of neural activity or sensory experience. Plasticity cortical excitatory synapses is thought to be important for learning memory, leading alterations representations cognitive maps. However, these must coordinated across other within local circuits preserve coding schemes the organization inhibitory inputs, i.e., excitatory-inhibitory balance. Recent studies indicate that also controlled directly a large number neuromodulators, particularly during episodes learning. Many modulators transiently alter balance decreasing inhibition, thus disinhibition has emerged as major mechanism which neuromodulation might enable long-term synaptic modifications naturally. This review examines relationships between plasticity, focusing on induction collectively enhance improving perception behavior.

Language: Английский

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Active cortical dendrites modulate perception

Science, Journal Year: 2016, Volume and Issue: 354(6319), P. 1587 - 1590

Published: Dec. 22, 2016

Now you feel it, now don't What determines the detection of a sensory stimulus? To address this question, Takahashi et al. combined in vivo two-photon imaging, electrophysiology, optogenetics, and behavioral analysis study mice. Calcium signals apical dendrites pyramidal neurons somatosensory cortex controlled perceptual threshold mice's whiskers. Strong reduction dendritic calcium signaling impaired so that an identical stimulus could no longer be noticed. Science , issue p. 1587

Language: Английский

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The connectome of the adult Drosophila mushroom body provides insights into function

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Dec. 14, 2020

Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) well positioned for developing and testing such approach due to its conserved architecture, recently completed dense connectome, extensive prior experimental studies of roles learning, memory, activity regulation. Here, we identify new components MB circuit Drosophila, including visual input output neurons (MBONs) with direct connections descending neurons. We find unexpected structure sensory inputs, transfer information different modalities MBONs, modulation that dopaminergic (DANs). provide insights into circuitry used integrate outputs, between central complex inputs DANs, feedback MBONs. Our results a foundation further theoretical work.

Language: Английский

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General Anesthesia Decouples Cortical Pyramidal Neurons

Cell, Journal Year: 2020, Volume and Issue: 180(4), P. 666 - 676.e13

Published: Feb. 1, 2020

The mystery of general anesthesia is that it specifically suppresses consciousness by disrupting feedback signaling in the brain, even when feedforward and basic neuronal function are left relatively unchanged. mechanism for such selectiveness unknown. Here we show three different anesthetics have same disruptive influence on along apical dendrites cortical layer 5 pyramidal neurons mice. We found optogenetic depolarization distal caused robust spiking at cell body under awake conditions was blocked anesthesia. Moreover, blocking metabotropic glutamate cholinergic receptors had effect dendrite decoupling as or inactivation higher-order thalamus. If occurs predominantly through dendrites, cellular would explain not only how selectively blocks this but also why conscious perception depends both cortico-cortical thalamo-cortical connectivity.

Language: Английский

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Orientation selectivity and the functional clustering of synaptic inputs in primary visual cortex

Nature Neuroscience, Journal Year: 2016, Volume and Issue: 19(8), P. 1003 - 1009

Published: June 13, 2016

Language: Английский

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