Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 16(11), P. 661 - 675

Published: Oct. 3, 2016

Language: Английский

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The Gut Microbiota in Immune-Mediated Inflammatory Diseases

Frontiers in Microbiology, Journal Year: 2016, Volume and Issue: 7

Published: July 11, 2016

The collection of microbes and their genes that exist within on the human body, collectively known as microbiome has emerged a principal factor in health disease. Humans have established symbiotic association over time, perturbations this been linked to several immune-mediated inflammatory diseases (IMID) including bowel disease, rheumatoid arthritis multiple sclerosis. IMID is term used describe group chronic, highly disabling affect different organ systems. Though cornerstone commonality between idiopathic nature considerable portion pathobiology overlaps epidemiological co-occurrence, genetic susceptibility loci environmental risk factors. At present, it clear persons with an are at increased for developing comorbidities, additional IMID. Advancements sequencing technologies parallel explosion 16S rDNA metagenomics community profiling studies allowed characterization microbiomes throughout body gut, myriad health. main challenge now determine if alterations gut flora common or, particular changes fact specific single Herein, we review discuss relationships microbiota Keywords: microbiome, systems microbiology metagenome, chronic immune mediated

Language: Английский

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The role of the lung microbiota and the gut-lung axis in respiratory infectious diseases

Cellular Microbiology, Journal Year: 2018, Volume and Issue: 20(12), P. e12966 - e12966

Published: Oct. 17, 2018

The pulmonary microbial community, described only a few years ago, forms discreet part of the human host microbiota. airway microbiota has been found to be substantially altered in context numerous respiratory disorders; nonetheless, its role health and disease is as yet poorly understood. Another important parameter consider gut-lung axis, where distal (gut) immune modulation during mediated by gut use specific strains, termed "probiotics," with beneficial effects on immunity and/or against pathogens, proven successful treatment intestinal disorders also showing promise diseases. In this review, we highlight body's commensal bacteria infectious diseases, including recent evidence highlighting their local (lung) or contribution process.

Language: Английский

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Autophagy and Inflammation

Annual Review of Immunology, Journal Year: 2017, Volume and Issue: 36(1), P. 73 - 101

Published: Nov. 16, 2017

The cellular degradative pathway of autophagy has a fundamental role in immunity. Here, we review the function and proteins inflammation. We discuss how machinery controls burden infectious agents while simultaneously limiting inflammatory pathologies, which often involves processes that are distinct from conventional autophagy. Among newly emerging describe LC3-associated phagocytosis targeting by proteins, both require many same mediate also contributes to differentiation myeloid lymphoid cell types, coordinates multicellular immunity, facilitates memory responses. Together, these functions establish an intimate link between autophagy, mucosal chronic diseases. Finally, offer our perspective on current challenges barriers translation.

Language: Английский

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Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells

Nature Immunology, Journal Year: 2015, Volume and Issue: 17(1), P. 65 - 75

Published: Nov. 23, 2015

Language: Английский

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