Innate Lymphoid Cells: 10 Years On

Cell, Journal Year: 2018, Volume and Issue: 174(5), P. 1054 - 1066

Published: Aug. 1, 2018

Language: Английский

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Inflammation and tumor progression: signaling pathways and targeted intervention

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: July 12, 2021

Abstract Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes. Chronic inflammation facilitates progression treatment resistance, whereas induction of acute inflammatory reactions often stimulates the maturation dendritic cells (DCs) antigen presentation, leading anti-tumor immune responses. In addition, multiple signaling pathways, such as nuclear factor kappa B (NF-kB), Janus kinase/signal transducers activators transcription (JAK-STAT), toll-like receptor (TLR) cGAS/STING, mitogen-activated protein kinase (MAPK); factors, including cytokines (e.g., interleukin (IL), interferon (IFN), necrosis (TNF)-α), chemokines C-C motif chemokine ligands (CCLs) C-X-C (CXCLs)), growth factors vascular endothelial (VEGF), transforming (TGF)-β), inflammasome; well metabolites prostaglandins, leukotrienes, thromboxane, specialized proresolving mediators (SPM), have been identified pivotal regulators initiation resolution inflammation. Nowadays, local irradiation, recombinant cytokines, neutralizing antibodies, small-molecule inhibitors, DC vaccines, oncolytic viruses, TLR agonists, SPM developed specifically modulate in cancer therapy, with some these already undergoing clinical trials. Herein, we discuss crosstalk between processes. We also highlight potential targets for harnessing cancer.

Language: Английский

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The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

Nucleic Acids Research, Journal Year: 2017, Volume and Issue: 46(D1), P. D1091 - D1106

Published: Oct. 25, 2017

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets ligands from selected papers in pharmacology drug discovery since 2003. This resource continues be developed conjunction with the International Union of Basic Clinical Pharmacology (IUPHAR) British Pharmacological Society (BPS). As previously described, our unique model content selection quality control is based on 96 target-class subcommittees comprising 512 scientists collaborating in-house curators. update describes expansion, new features interoperability improvements introduced 10 releases August 2015. Our relationship matrix now ∼9000 ligands, ∼15 000 binding constants, ∼6000 ∼1700 human proteins. an important addition, we also introduce newly funded project for IMMUNOPHARMACOLOGY (GtoImmuPdb, www.guidetoimmunopharmacology.org). has been 'forked' well-established GtoPdb data expanded into types related immune system inflammatory processes. includes targets, pathways, cell diseases which are recruiting IUPHAR expert committees. Designed as immunopharmacological gateway, it emphasis potential therapeutic interventions.

Language: Английский

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Inflammatory mechanisms in patients with chronic obstructive pulmonary disease

Journal of Allergy and Clinical Immunology, Journal Year: 2016, Volume and Issue: 138(1), P. 16 - 27

Published: May 28, 2016

Language: Английский

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NK cells and cancer: you can teach innate cells new tricks

Nature reviews. Cancer, Journal Year: 2015, Volume and Issue: 16(1), P. 7 - 19

Published: Dec. 23, 2015

Language: Английский

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Natural killer cells and other innate lymphoid cells in cancer

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(11), P. 671 - 688

Published: Sept. 12, 2018

Language: Английский

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Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Cell, Journal Year: 2017, Volume and Issue: 171(1), P. 217 - 228.e13

Published: Sept. 1, 2017

Language: Английский

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Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

Nature Immunology, Journal Year: 2016, Volume and Issue: 17(7), P. 765 - 774

Published: June 21, 2016

Language: Английский

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Barrier Epithelial Cells and the Control of Type 2 Immunity

Immunity, Journal Year: 2015, Volume and Issue: 43(1), P. 29 - 40

Published: July 1, 2015

Language: Английский

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Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

Science, Journal Year: 2015, Volume and Issue: 350(6263), P. 981 - 985

Published: Oct. 16, 2015

Innate lymphoid cells (ILCs) contribute to barrier immunity, tissue homeostasis, and immune regulation at various anatomical sites throughout the body. How ILCs maintain their presence in peripheral tissues thus far has been unclear. We found that nonlymphoid organs of adult mice, are tissue-resident were maintained expanded locally under physiologic conditions, upon systemic perturbation homeostasis during acute helminth infection. However, later time points after infection, from hematogenous sources helped partially replenish pool resident ILCs. Thus, by self-renewal broadly different microenvironments physiological settings. Such an extreme "sedentary" lifestyle is consistent with proposed roles as sentinels local keepers function.

Language: Английский

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