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Vivian Tam, Nikunj Patel,

Michelle Turcotte

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Nature Reviews Genetics, Journal Year: 2019, Volume and Issue: 20(8), P. 467 - 484

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Language: Английский

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Nature Genetics, Journal Year: 2015, Volume and Issue: 47(11), P. 1228 - 1235

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Language: Английский

Citations

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A survey of best practices for RNA-seq data analysis DOI Creative Commons
Ana Conesa, Pedro Madrigal,

Sonia Tarazona

et al.

Genome biology, Journal Year: 2016, Volume and Issue: 17(1)

Published: Jan. 26, 2016

RNA-sequencing (RNA-seq) has a wide variety of applications, but no single analysis pipeline can be used in all cases. We review the major steps RNA-seq data analysis, including experimental design, quality control, read alignment, quantification gene and transcript levels, visualization, differential expression, alternative splicing, functional fusion detection eQTL mapping. highlight challenges associated with each step. discuss small RNAs integration other genomics techniques. Finally, we outlook for novel technologies that are changing state art transcriptomics.

Language: Английский

Citations

2460
The molecular hallmarks of epigenetic control DOI
C. David Allis, Thomas Jenuwein

Nature Reviews Genetics, Journal Year: 2016, Volume and Issue: 17(8), P. 487 - 500

Published: June 27, 2016

Language: Английский

Citations

2323
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions DOI
David M. Howard, Mark J. Adams, Toni‐Kim Clarke

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Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(3), P. 343 - 352

Published: Feb. 4, 2019

Language: Английский

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Predicting effects of noncoding variants with deep learning–based sequence model DOI
Jian Zhou, Olga G. Troyanskaya

Nature Methods, Journal Year: 2015, Volume and Issue: 12(10), P. 931 - 934

Published: Aug. 24, 2015

Language: Английский

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2140
An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues DOI
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Nature Methods, Journal Year: 2017, Volume and Issue: 14(10), P. 959 - 962

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Language: Английский

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Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk DOI
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Nature Genetics, Journal Year: 2019, Volume and Issue: 51(3), P. 404 - 413

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Identification of common genetic risk variants for autism spectrum disorder DOI
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Nature Genetics, Journal Year: 2019, Volume and Issue: 51(3), P. 431 - 444

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Language: Английский

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2062
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder DOI
Ditte Demontis, Raymond K. Walters, Joanna Martin

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Nature Genetics, Journal Year: 2018, Volume and Issue: 51(1), P. 63 - 75

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Language: Английский

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2034
Immunopathology of multiple sclerosis DOI
Calliope A. Dendrou, Lars Fugger, Manuel A. Friese

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Nature reviews. Immunology, Journal Year: 2015, Volume and Issue: 15(9), P. 545 - 558

Published: Aug. 7, 2015

Language: Английский

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