Journal of Hematology & Oncology,
Journal Year:
2020,
Volume and Issue:
13(1)
Published: Aug. 10, 2020
Abstract
In
recent
years,
cancer
immunotherapy
based
on
immune
checkpoint
inhibitors
(ICIs)
has
achieved
considerable
success
in
the
clinic.
However,
ICIs
are
significantly
limited
by
fact
that
only
one
third
of
patients
with
most
types
respond
to
these
agents.
The
induction
cell
death
mechanisms
other
than
apoptosis
gradually
emerged
as
a
new
treatment
strategy
because
tumors
harbor
innate
resistance
apoptosis.
date,
possibility
combining
two
modalities
not
been
discussed
systematically.
Recently,
few
studies
revealed
crosstalk
between
distinct
and
antitumor
immunity.
pyroptosis,
ferroptosis,
necroptosis
combined
showed
synergistically
enhanced
activity,
even
ICI-resistant
tumors.
Immunotherapy-activated
CD8+
T
cells
traditionally
believed
induce
tumor
via
following
main
pathways:
(i)
perforin-granzyme
(ii)
Fas-FasL.
identified
mechanism
which
suppress
growth
inducing
ferroptosis
provoked
review
relationship
system
activation.
Hence,
this
review,
we
summarize
knowledge
reciprocal
interaction
immunity
mechanisms,
particularly
necroptosis,
three
potentially
novel
immunogenic
death.
Because
evidence
is
derived
from
using
animal
models,
also
reviewed
related
bioinformatics
data
available
for
human
tissues
public
databases,
partially
confirmed
presence
interactions
activation
Cell Research,
Journal Year:
2019,
Volume and Issue:
29(5), P. 347 - 364
Published: April 4, 2019
Cells
may
die
from
accidental
cell
death
(ACD)
or
regulated
(RCD).
ACD
is
a
biologically
uncontrolled
process,
whereas
RCD
involves
tightly
structured
signaling
cascades
and
molecularly
defined
effector
mechanisms.
A
growing
number
of
novel
non-apoptotic
forms
have
been
identified
are
increasingly
being
implicated
in
various
human
pathologies.
Here,
we
critically
review
the
current
state
art
regarding
types
RCD,
including
necroptosis,
pyroptosis,
ferroptosis,
entotic
death,
netotic
parthanatos,
lysosome-dependent
autophagy-dependent
alkaliptosis
oxeiptosis.
The
in-depth
comprehension
each
these
lethal
subroutines
their
intercellular
consequences
uncover
therapeutic
targets
for
avoidance
pathogenic
loss.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: March 29, 2021
Abstract
Currently,
pyroptosis
has
received
more
and
attention
because
of
its
association
with
innate
immunity
disease.
The
research
scope
expanded
the
discovery
gasdermin
family.
A
great
deal
evidence
shows
that
can
affect
development
tumors.
relationship
between
tumors
is
diverse
in
different
tissues
genetic
backgrounds.
In
this
review,
we
provide
basic
knowledge
pyroptosis,
explain
tumors,
focus
on
significance
tumor
treatment.
addition,
further
summarize
possibility
as
a
potential
treatment
strategy
describe
side
effects
radiotherapy
chemotherapy
caused
by
pyroptosis.
brief,
double-edged
sword
for
rational
use
dual
effect
will
help
us
explore
formation
ideas
patients
to
develop
new
drugs
based
Immunological Reviews,
Journal Year:
2017,
Volume and Issue:
277(1), P. 61 - 75
Published: April 30, 2017
Summary
Cell
death
is
a
fundamental
biological
phenomenon
that
essential
for
the
survival
and
development
of
an
organism.
Emerging
evidence
also
indicates
cell
contributes
to
immune
defense
against
infectious
diseases.
Pyroptosis
form
inflammatory
programmed
pathway
activated
by
human
mouse
caspase‐1,
caspase‐4
caspase‐5,
or
caspase‐11.
These
caspases
are
used
host
control
bacterial,
viral,
fungal,
protozoan
pathogens.
requires
cleavage
activation
pore‐forming
effector
protein
gasdermin
D
caspases.
Physical
rupture
causes
release
pro‐inflammatory
cytokines
IL
‐1β
‐18,
alarmins
endogenous
danger‐associated
molecular
patterns,
signifying
potential
pyroptosis.
Here,
we
describe
central
role
pyroptosis
in
mediating
immunity
infection
clearance
Cellular and Molecular Immunology,
Journal Year:
2021,
Volume and Issue:
18(5), P. 1106 - 1121
Published: March 30, 2021
Abstract
Cell
death
is
a
fundamental
physiological
process
in
all
living
organisms.
Its
roles
extend
from
embryonic
development,
organ
maintenance,
and
aging
to
the
coordination
of
immune
responses
autoimmunity.
In
recent
years,
our
understanding
mechanisms
orchestrating
cellular
its
consequences
on
immunity
homeostasis
has
increased
substantially.
Different
modalities
what
become
known
as
‘programmed
cell
death’
have
been
described,
some
key
players
these
processes
identified.
We
learned
more
about
intricacies
that
fine
tune
activity
common
ultimately
shape
different
types
death.
These
studies
highlighted
complex
tipping
balance
between
fates.
Here,
we
summarize
latest
discoveries
three
most
well
understood
death,
namely,
apoptosis,
necroptosis,
pyroptosis,
highlighting
unique
pathways
their
effect
surrounding
cells
organism
whole.
Nature Communications,
Journal Year:
2017,
Volume and Issue:
8(1)
Published: Jan. 3, 2017
Abstract
Apoptosis
is
a
genetically
regulated
cell
suicide
programme
mediated
by
activation
of
the
effector
caspases
3,
6
and
7.
If
apoptotic
cells
are
not
scavenged,
they
progress
to
lytic
inflammatory
phase
called
secondary
necrosis.
The
mechanism
which
this
occurs
unknown.
Here
we
show
that
caspase-3
cleaves
GSDMD-related
protein
DFNA5
after
Asp270
generate
necrotic
DFNA5-N
fragment
targets
plasma
membrane
induce
necrosis/pyroptosis.
Cells
express
necrosis,
when
stimulated
with
triggers
such
as
etoposide
or
vesicular
stomatitis
virus
infection,
but
disassemble
into
small
bodies
deleted.
Our
findings
identify
central
molecule
regulates
disassembly
progression
provide
molecular
for
Because
DFNA5-induced
necrosis
GSDMD-induced
pyroptosis
dependent
on
caspase
activation,
propose
forms
programmed
