Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: Feb. 16, 2021
Abstract
As
the
crucial
powerhouse
for
cell
metabolism
and
tissue
survival,
mitochondrion
frequently
undergoes
morphological
or
positional
changes
when
responding
to
various
stresses
energy
demands.
In
addition
intracellular
changes,
mitochondria
can
also
be
transferred
intercellularly.
Besides
restoring
stressed
cells
damaged
tissues
due
mitochondrial
dysfunction,
intercellular
transfer
occurs
under
physiological
conditions.
this
review,
phenomenon
of
is
described
according
its
function
both
pathological
conditions,
including
homeostasis,
repair,
tumor
progression,
immunoregulation.
Then,
mechanisms
that
contribute
process
are
summarized,
such
as
trigger
factors
routes.
Furthermore,
perspectives
explored
better
understand
mysteries
cell–cell
trafficking.
addition,
potential
therapeutic
strategies
mitochondria-targeted
application
rescue
damage
degeneration,
well
inhibition
discussed.
Signal Transduction and Targeted Therapy,
Journal Year:
2020,
Volume and Issue:
5(1)
Published: Aug. 25, 2020
Abstract
Accumulating
evidence
shows
that
cellular
and
acellular
components
in
tumor
microenvironment
(TME)
can
reprogram
initiation,
growth,
invasion,
metastasis,
response
to
therapies.
Cancer
research
treatment
have
switched
from
a
cancer-centric
model
TME-centric
one,
considering
the
increasing
significance
of
TME
cancer
biology.
Nonetheless,
clinical
efficacy
therapeutic
strategies
targeting
TME,
especially
specific
cells
or
pathways
remains
unsatisfactory.
Classifying
chemopathological
characteristics
crosstalk
among
one
another
greatly
benefit
further
studies
exploring
effective
treating
methods.
Herein,
we
present
an
updated
image
with
emphasis
on
hypoxic
niche,
immune
microenvironment,
metabolism
acidic
innervated
mechanical
microenvironment.
We
then
summarize
conventional
drugs
including
aspirin,
celecoxib,
β-adrenergic
antagonist,
metformin,
statin
new
antitumor
application.
These
are
considered
as
viable
candidates
for
combination
therapy
due
their
activity
extensive
use
practice.
also
provide
our
outlook
directions
potential
applications
theory.
This
review
depicts
comprehensive
vivid
landscape
biology
treatment.
Genes & Development,
Journal Year:
2019,
Volume and Issue:
33(11-12), P. 591 - 609
Published: June 1, 2019
Glioblastoma
ranks
among
the
most
lethal
of
all
human
cancers.
Glioblastomas
display
striking
cellular
heterogeneity,
with
stem-like
glioblastoma
stem
cells
(GSCs)
at
apex.
Although
original
identification
GSCs
dates
back
more
than
a
decade,
purification
and
characterization
remains
challenging.
Despite
these
challenges,
evidence
that
play
important
roles
in
tumor
growth
response
to
therapy
has
grown.
Like
normal
cells,
are
functionally
defined
distinguished
from
their
differentiated
progeny
core
transcriptional,
epigenetic,
metabolic
regulatory
levels,
suggesting
no
single
therapeutic
modality
will
be
universally
effective
against
heterogenous
GSC
population.
induce
systemic
immunosuppression
mixed
responses
oncoimmunologic
modalities,
potential
for
augmentation
deeper
consideration
GSCs.
Unfortunately,
literature
been
complicated
by
frequent
use
inferior
cell
lines
lack
proper
functional
analyses.
Collectively,
offers
reliable
cancer
study
better
model
disease
inform
improved
biologic
understanding
design
novel
therapeutics.
Journal of Clinical Investigation,
Journal Year:
2017,
Volume and Issue:
127(2), P. 415 - 426
Published: Jan. 31, 2017
Glioblastoma
is
the
most
common
and
lethal
primary
malignant
brain
tumor
in
adults.
Patients
die
from
recurrent
tumors
that
have
become
resistant
to
therapy.
New
strategies
are
needed
design
future
therapies
target
cells.
Recent
genomic
studies
unveiled
complexity
of
heterogeneity
glioblastoma
provide
new
insights
into
landscape
cells
survive
initiate
recurrence.
Resistant
also
co-opt
developmental
pathways
display
stem-like
properties;
hence
we
propose
name
them
recurrence-initiating
cancer
(RISC)
Genetic
alterations
reprogramming
underlie
innate
adaptive
resistance
RISC
cells,
both
need
be
targeted
prevent
