Understanding the tumor immune microenvironment (TIME) for effective therapy

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(5), P. 541 - 550

Published: April 20, 2018

Language: Английский

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Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

Cell, Journal Year: 2017, Volume and Issue: 168(4), P. 707 - 723

Published: Feb. 1, 2017

Language: Английский

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The PI3K Pathway in Human Disease

Cell, Journal Year: 2017, Volume and Issue: 170(4), P. 605 - 635

Published: Aug. 1, 2017

Language: Английский

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Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab

Cell, Journal Year: 2017, Volume and Issue: 171(4), P. 934 - 949.e16

Published: Oct. 13, 2017

Language: Английский

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Macrophages as regulators of tumour immunity and immunotherapy

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(6), P. 369 - 382

Published: Feb. 4, 2019

Language: Английский

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Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: May 24, 2019

Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue macrophages seeded the early embryo before definitive hematopoiesis is established. Others derived from blood monocytes. The macrophage lineage diversification plasticity key aspects of their functionality. can also be generated monocytes vitro undergo classical (LPS+IFN-γ) or alternative (IL-4) activation. In vivo, with different polarization activation markers coexist tissues. Certain mouse strains preferentially promote T-helper-1 (Th1) responses other Th2 responses. Their induce iNOS arginase have been called M1 M2, respectively. many publications, classically activated M2 alternatively used interchangeably. We tested whether this justified by comparing gene lists positively [M1(=LPS+)] negatively [M2(=LPS-)] correlated ratio IL-12 1 transcriptomes LPS-treated peritoneal (LPS, IFN-γ) versus bone marrow-derived macrophages, both published datasets. Although there some overlap between vivo M1(=LPS+) (LPS+IFNγ) M2(=LPS-) more genes regulated opposite unrelated ways. Thus, not equivalent to activated, macrophages. This fundamental discrepancy explains why most surface identified on do translate situation. Valid M1/M2 remain discovered.

Language: Английский

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Targeting macrophages: therapeutic approaches in cancer

Nature Reviews Drug Discovery, Journal Year: 2018, Volume and Issue: 17(12), P. 887 - 904

Published: Oct. 26, 2018

Language: Английский

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Microenvironmental regulation of tumour angiogenesis

Nature reviews. Cancer, Journal Year: 2017, Volume and Issue: 17(8), P. 457 - 474

Published: July 14, 2017

Language: Английский

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Macrophages and Metabolism in the Tumor Microenvironment

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(1), P. 36 - 50

Published: July 1, 2019

Language: Английский

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Targeting PI3K in cancer: mechanisms and advances in clinical trials

Molecular Cancer, Journal Year: 2019, Volume and Issue: 18(1)

Published: Feb. 19, 2019

Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one the most important intracellular pathways, which can be considered as a master regulator for cancer. Enormous efforts have been dedicated to development drugs targeting PI3K signaling, many are currently employed in clinical trials evaluation, and it becoming increasingly clear that inhibitors effective inhibiting tumor progression. subdivided into dual PI3K/mTOR inhibitors, pan-PI3K isoform-specific inhibitors. In this review, we performed critical review summarize role pathway development, recent based on trials, mechanisms resistance inhibition.

Language: Английский

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