The neurons that restore walking after paralysis

Nature, Journal Year: 2022, Volume and Issue: 611(7936), P. 540 - 547

Published: Nov. 9, 2022

Abstract A spinal cord injury interrupts pathways from the brain and brainstem that project to lumbar cord, leading paralysis. Here we show spatiotemporal epidural electrical stimulation (EES) of 1–3 applied during neurorehabilitation 4,5 (EES REHAB ) restored walking in nine individuals with chronic injury. This recovery involved a reduction neuronal activity humans walking. We hypothesized this unexpected reflects activity-dependent selection specific subpopulations become essential for patient walk after To identify these putative neurons, modelled technological therapeutic features underlying EES mice. single-nucleus RNA sequencing 6–9 spatial transcriptomics 10,11 cords mice chart spatially resolved molecular atlas then employed cell type 12,13 prioritization neurons single population excitatory interneurons nested within intermediate laminae emerged. Although are not required before injury, demonstrate they following Augmenting phenocopied enabled by , whereas ablating them prevented occurs spontaneously moderate thus identified recovery-organizing subpopulation is necessary sufficient regain Moreover, our methodology establishes framework using cartography produce complex behaviours.

Language: Английский

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Electronic neural interfaces

Nature Electronics, Journal Year: 2020, Volume and Issue: 3(4), P. 191 - 200

Published: April 13, 2020

Language: Английский

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Physical principles of brain–computer interfaces and their applications for rehabilitation, robotics and control of human brain states

Physics Reports, Journal Year: 2021, Volume and Issue: 918, P. 1 - 133

Published: March 24, 2021

Language: Английский

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Progression in translational research on spinal cord injury based on microenvironment imbalance

Bone Research, Journal Year: 2022, Volume and Issue: 10(1)

Published: April 8, 2022

Spinal cord injury (SCI) leads to loss of motor and sensory function below the level imposes a considerable burden on patients, families, society. Repair injured spinal has been recognized as global medical challenge for many years. Significant progress made in research pathological mechanism injury. In particular, with development gene regulation, cell sequencing, tracing technologies, in-depth explorations SCI microenvironment have become more feasible. However, translational studies related repair not yielded significant results. This review summarizes latest two aspects pathology: intraneuronal imbalance regenerative imbalance. We also strategies based imbalance, including medications, transplantation, exosomes, tissue engineering, reprogramming, rehabilitation. The current state future directions are discussed. combined, precise, multitemporal strategy repairing is potential direction.

Language: Английский

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High-speed and large-scale intrinsically stretchable integrated circuits

Nature, Journal Year: 2024, Volume and Issue: 627(8003), P. 313 - 320

Published: March 13, 2024

Language: Английский

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