Mitochondrial TCA cycle metabolites control physiology and disease

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Jan. 3, 2020

Abstract Mitochondria are signaling organelles that regulate a wide variety of cellular functions and can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness the rest cell. Recent evidence confers new role for TCA cycle intermediates, generally thought be important biosynthetic purposes, as molecules with controlling chromatin modifications, DNA methylation, hypoxic response, immunity. This review summarizes by which abundance different metabolites controls function fate in contexts. We will focus on how these mediated affect physiology disease.

Language: Английский

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Macrophages and Metabolism in the Tumor Microenvironment

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(1), P. 36 - 50

Published: July 1, 2019

Language: Английский

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Metabolic Instruction of Immunity

Cell, Journal Year: 2017, Volume and Issue: 169(4), P. 570 - 586

Published: May 1, 2017

Language: Английский

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The Principles of Engineering Immune Cells to Treat Cancer

Cell, Journal Year: 2017, Volume and Issue: 168(4), P. 724 - 740

Published: Feb. 1, 2017

Language: Английский

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The hypoxic tumour microenvironment

Oncogenesis, Journal Year: 2018, Volume and Issue: 7(1)

Published: Jan. 22, 2018

Cancer progression often benefits from the selective conditions present in tumour microenvironment, such as presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression immune response. Generation a hypoxic environment activation its main effector, hypoxia-inducible factor-1 (HIF-1), are common features advanced cancers. In addition to impact on cell biology, influence that hypoxia exerts surrounding cells represents critical step tumorigenic process. Hypoxia indeed enables number events microenvironment lead expansion aggressive clones heterogeneous promote lethal phenotype. this article, we review most relevant findings describing contribution HIF major components summarise their role cancer development progression.

Language: Английский

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Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Science, Journal Year: 2019, Volume and Issue: 366(6468), P. 1013 - 1021

Published: Nov. 8, 2019

The metabolic characteristics of tumors present considerable hurdles to immune cell function and cancer immunotherapy. Using a glutamine antagonist, we metabolically dismantled the immunosuppressive microenvironment tumors. We demonstrate that blockade in tumor-bearing mice suppresses oxidative glycolytic metabolism cells, leading decreased hypoxia, acidosis, nutrient depletion. By contrast, effector T cells responded antagonism by markedly up-regulating adopting long-lived, highly activated phenotype. These divergent changes cellular programming form basis for potent antitumor responses. Glutamine therefore exposes previously undefined difference plasticity between can be exploited as "metabolic checkpoint" tumor

Language: Английский

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Metabolism of immune cells in cancer

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(9), P. 516 - 531

Published: July 6, 2020

Language: Английский

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Metabolic coordination of T cell quiescence and activation

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 20(1), P. 55 - 70

Published: Aug. 12, 2019

Language: Английский

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Regulation of immunity and inflammation by hypoxia in immunological niches

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 17(12), P. 774 - 785

Published: Oct. 3, 2017

Language: Английский

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The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

Cancer Cell International, Journal Year: 2021, Volume and Issue: 21(1)

Published: Jan. 20, 2021

Abstract Hypoxia is a common feature of solid tumors, and develops because the rapid growth tumor that outstrips oxygen supply, impaired blood flow due to formation abnormal vessels supplying tumor. It has been reported hypoxia can: activate angiogenesis, thereby enhancing invasiveness risk metastasis; increase survival tumor, as well suppress anti-tumor immunity hamper therapeutic response. mediates these effects by several potential mechanisms: altering gene expression, activation oncogenes, inactivation suppressor genes, reducing genomic stability clonal selection. We have reviewed on biology possible strategiesto manage hypoxic microenvironment (TME), highlighting use cancer stem cells in treatment.

Language: Английский

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