Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

Science, Journal Year: 2019, Volume and Issue: 363(6432), P. 1217 - 1222

Published: March 14, 2019

Oxygen sensing revisited The cellular response to hypoxia (oxygen deficiency) is a contributing factor in many human diseases. Previous studies examining the way which alters gene expression have focused on oxygen-sensing enzymes that regulate activity of transcription called hypoxia-inducible (see Perspective by Gallipoli and Huntly). Chakraborty et al. Batie now show can also affect through direct effects chromatin regulators. Certain histone demethylases, such as KDM6A KDM5A, were found be sensors oxygen. In cell-culture models, diminished these caused changes genes govern cell fate. Science , this issue p. 1217 1222 ; see 1148

Language: Английский

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Mitochondrial control of immunity: beyond ATP

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 17(10), P. 608 - 620

Published: July 3, 2017

Language: Английский

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Therapeutic targeting of the hypoxic tumour microenvironment

Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 18(12), P. 751 - 772

Published: July 29, 2021

Language: Английский

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Mitochondrial signal transduction

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(11), P. 1620 - 1653

Published: Nov. 1, 2022

The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue the processor cell, together with nucleus other they constitute mitochondrial information processing system (MIPS). In a three-step process, (1) sense respond to both endogenous environmental inputs through morphological functional remodeling; (2) integrate network-based physical interactions diffusion mechanisms; (3) produce output signals tune functions systemically regulate physiology. This input-to-output transformation allows metabolic, biochemical, neuroendocrine, local or systemic enhance organismal adaptation. An explicit focus on signal transduction emphasizes role communication in biology. framework also opens new avenues understand how mediate inter-organ processes underlying human health.

Language: Английский

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Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors

Cell Metabolism, Journal Year: 2017, Volume and Issue: 26(1), P. 49 - 70

Published: July 1, 2017

Language: Английский

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